ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017
Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas.
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In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Glioblastoma research on zebrafish xenograft models: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Pooled it
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- [EJNMMI radiopharmacy and chemistry · 2025Article
- In vivo imaging of heat shock protein 90: Diagnostic tool and support for Hsp90-targeted therapy.Cell stress & chaperones · 2025Review
- Overcoming cancer drug resistance through small-molecule targeting of HSP90 and HSP70.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy.Frontiers in oncology · 2025Article
- Epichaperome Inhibition by PU-H71-Mediated Targeting of HSP90 Sensitizes Glioblastoma Cells to Alkylator-Induced DNA Damage.Cancers · 2024Article
- Speeding up Glioblastoma Cancer Research: Highlighting the Zebrafish Xenograft Model.International journal of molecular sciences · 2024Review
- Review
- Polydatin-Mediated Inhibition of HSP90α Disrupts NLRP3 Complexes and Alleviates Acute Pancreatitis.Research (Washington, D.C.) · 2024Article
- An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.NPJ precision oncology · 2023Review
- ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors.Nature communications · 2023Article
- Radiosynthesis and preclinical evaluation of [EJNMMI radiopharmacy and chemistry · 2023Article
- Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration.Metabolites · 2022Review
- Targeting Heat Shock Proteins in Malignant Brain Tumors: From Basic Research to Clinical Trials.Cancers · 2022Review
- Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1.Cell death & disease · 2022Article
- Orthotopic Transplantation of Human Paediatric High-Grade Glioma in Zebrafish Larvae.Brain sciences · 2022Article
- Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Integrative analysis of therapy resistance and transcriptomic profiling data in glioblastoma cells identifies sensitization vulnerabilities for combined modality radiochemotherapy.Radiation oncology (London, England) · 2022Article
- Age-Dependent Chronic Lung Injury and Pulmonary Fibrosis following Single Exposure to Hydrochloric Acid.International journal of molecular sciences · 2021Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Alessandro CanellaDivision of Neuro-oncology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Alessandra M WelkerDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Ji Young YooDepartment of Neurosurgery and the Dardinger Laboratory for Neuro-Oncology and Neurosciences, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Jihong XuDivision of Neuro-oncology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Fazly S AbasDepartment of Biomedical Informatics, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Divya KesanakurtiDivision of Neuro-oncology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Prabakaran NagarajanDivision of Neuro-oncology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Christine E BeattieDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Erik P SulmanDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Joseph LiuDepartment of Neurosurgery and the Dardinger Laboratory for Neuro-Oncology and Neurosciences, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Joy GuminDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Frederick F LangDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Metin N GurcanDepartment of Biomedical Informatics, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Balveen KaurDepartment of Neurosurgery and the Dardinger Laboratory for Neuro-Oncology and Neurosciences, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Deepa SampathDivision of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Vinay K PuduvalliDivision of Neuro-oncology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Vinay.Puduvalli@osumc.edu.
The Ohio State University · USThe Ohio State University Wexner Medical Center · USThe University of Texas MD Anderson Cancer Center · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MTropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2MOhio State Neuroscience Centr CoreP30NS045758 · NINDS · OHIO STATE UNIVERSITY · PI OBRIETAN, KARL H · 2004 to 2015
$7.7MCharacterization of Onalespib, A novel long acting Hsp90 inhibitor, as a chemo and radiosensitizer in Adults with Newly Diagnosed GlioblastomaR01CA235673 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PUDUVALLI, VINAY K, SAMPATH, DEEPA · 2019 to 2024
$2.9MPatient Oriented Research Program in Neuro-oncologyK24CA160777 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PUDUVALLI, VINAY K · 2012 to 2015
$580kNCI NIH HHS K24 CA160777NCI NIH HHS P30 CA016058NCI NIH HHS P50 CA127001NCI NIH HHS R01 CA235673NINDS NIH HHS P30 NS045758
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAntineoplastic AgentsBenzamidesBlood-Brain BarrierCell Line, TumorCell MovementCell ProliferationDacarbazineDisease Models, AnimalDrug SynergismDrug Therapy, CombinationErbB ReceptorsExtracellular Signal-Regulated MAP KinasesFemaleGene ExpressionGlioma(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanoneAntineoplastic AgentsBenzamidesDacarbazineErbB ReceptorsExtracellular Signal-Regulated MAP KinasesHSP90 Heat-Shock ProteinsIsoindolesProto-Oncogene Proteins c-aktRibosomal Protein S6 KinasesTemozolomide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.