Evidence map›Paper›PMID 28679761›Full record

ArticleJournal of virology2017

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.

Preeti Bharaj, Colm Atkins, Priya Luthra, Maria Isabel Giraldo, Brian E Dawes, Lisa Miorin, Jeffrey R Johnson, Nevan J Krogan, Christopher F Basler, Alexander N Freiberg and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 99 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. 25 Years of Ebola Virus VP35 Research.Journal of molecular biology · 2025
    Review
  6. Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Impaired K48-polyubiquitination downmodulates mouse norovirus propagation.Frontiers in cellular and infection microbiology · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Preeti BharajDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Colm AtkinsDepartment of Pathology, The Sealy Center for Vaccine Development, The Center for Biodefense and Emerging Infectious Diseases and The Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA.
Priya LuthraCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Maria Isabel GiraldoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Brian E DawesDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Lisa MiorinDepartment of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jeffrey R JohnsonCellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, USA.
Nevan J KroganCellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California, USA.
Christopher F BaslerCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Alexander N FreibergDepartment of Pathology, The Sealy Center for Vaccine Development, The Center for Biodefense and Emerging Infectious Diseases and The Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA.
Ricardo RajsbaumDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA rirajsba@utmb.edu.
The University of Texas Medical Branch at Galveston · USGeorgia State University · USUniversity of California, San Francisco · USIcahn School of Medicine at Mount Sinai · US

Funding

Molecular mechanisms of immune dysregulation by filoviral interferon U19AI109945 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASLER, CHRISTOPHER F · 2014 to 2018
$9.5M
EMERGING AND TROPICAL INFECTIOUS DISEASEST32AI007526 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SOONG, LYNN · 1997 to 2025
$3.1M
NIAID NIH HHS T32 AI007526NIAID NIH HHS U19 AI109945
6 · The paper itself

Abstract

Ebola virus (EBOV), a member of the

Indexed as

Host-Pathogen InteractionsUbiquitinationVirus ReplicationAnimalsCell LineEbolavirusHumansImmunoprecipitationMass SpectrometryTripartite Motif ProteinsUbiquitin-Protein LigasesViral Regulatory and Accessory ProteinsTRIM6 protein, humanTripartite Motif ProteinsUbiquitin-Protein LigasesViral Regulatory and Accessory ProteinsVP35 protein, filovirusEbola virusinnate immunityTRIM6tripartite motif (TRIM) proteinubiquitinationunanchored ubiquitinviral RNA polymerasevirus-host interactionsVP35

Identifiers

PMID28679761
PMCPMC5571272
OpenAlexW2725760085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.