Trial reportBlood2017
Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial.
Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support.The Cochrane database of systematic reviews · 2024Pooled it
- Correlation between thrombocytopenia and adverse outcomes in patients with atrial fibrillation: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022Pooled it
- What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022Pooled it
- The association between haemorrhage and markers of endothelial insufficiency and inflammation in patients with hypoproliferative thrombocytopenia: a cohort study.British journal of haematology · 2020Trial
- Preoperative Platelet and International Normalized Ratio Thresholds and Their Impact on Complications Following Revision Total Joint Arthroplasty.Arthroplasty today · 2026Article
- Bleeding history is associated with lower risk of cardiovascular events in a cohort undergoing lower extremity revascularization.Journal of thrombosis and thrombolysis · 2026Article
- Red blood cell transfusion thresholds in acute leukemia: Current practice and physician perspectives from a national survey.Transfusion · 2026Article
- Hemostatic and platelet proteins are associated with bleeding grade and time to major bleed in hemato-oncological patients.Blood vessels, thrombosis & hemostasis · 2026Article
- Venous thromboembolism and secondary outcomes of bleeding and mortality in patients with gliomas: a multicenter cohort study.Frontiers in oncology · 2026Article
- Anticoagulant therapy in patients with cancer and thrombocytopenia.Journal of thrombosis and thrombolysis · 2025Review
- An analysis of blood transfusion practices in gunshot wound patients at a peripheral trauma-blood centre unit.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Impact of platelet transfusions on plasma proteomes in controlled endotoxemia and in hemato-oncological patients.Transfusion · 2025Article
- Total thrombus formation analysis in patients with myeloid neoplasia and thrombocytopenia.Annals of hematology · 2025Article
- Risk of Thrombocytopenia by SSRIs or SNRIs in Patients With Depression Based on MID-NET: A Cohort Study in Japan.Clinical and translational science · 2025Observational
- Antiplatelet Therapy in Low-Platelet-Count Patients After Percutaneous Coronary Intervention for Acute Coronary Syndromes.Journal of clinical medicine · 2025Review
- Clinical Challenges in Treating Cancer-Associated Thrombosis: A Clinically Oriented Review.Acta haematologica · 2025Review
- Platelet count has a U-shaped association with mortality in hemodialysis patients.Scientific reports · 2024Article
- Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Lynne UhlHarvard Medical School, Boston, MA.
Susan F AssmannNew England Research Institutes, Watertown, MA.
Taye H HamzaNew England Research Institutes, Watertown, MA.
Ryan W HarrisonCorrona LLC, Southborough, MA.
Terry GernsheimerDivision of Hematology, University of Washington School of Medicine, Seattle, WA.
Sherrill J SlichterDivision of Hematology, University of Washington School of Medicine, Seattle, WA.
Funding
Transfusion Medicine/Hemostasis Research Network: DCCU01HL072268 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI ASSMANN, SUSAN FERA · 2002 to 2012
$33.2MTransfusion Medicine/Hemostasis Clinical Trials NetworkU01HL072291 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEUFELD, ELLIS J · 2002 to 2011
$2.6MOklahoma-UT Southwestern Hemostasis ConsortiumU01HL072283 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI GEORGE, JAMES N · 2002 to 2013
$2.6MTransfusion Medicine/Hemostasis Clinical Trails NetworkU01HL072248 · NHLBI · EMORY UNIVERSITY · PI JOSEPHSON, CASSANDRA D · 2002 to 2012
$2.4MTRANSFUSION MEDICINE/HEMOSTASIS TRIAL SITE AT PSBCU01HL072305 · NHLBI · PUGET SOUND BLOOD CENTER · PI SLICHTER, SHERRILL J. · 2002 to 2012
$2.4MClinical Trials in Transfusion Medicine and HemostasisU01HL072072 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCCULLOUGH, JEFFREY · 2002 to 2012
$2.3MHemostasis Clinical Research Network ProtocolsU01HL072274 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI LEISSINGER, CINDY A · 2002 to 2012
$2.2MNovel Therapies in Hemostasis and Transfusion MedicineU01HL072196 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUSSEL, JAMES BRUCE · 2002 to 2012
$2.1MJHMI Core Clinical Center for TMHCTNU01HL072191 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NESS, PAUL M · 2002 to 2012
$2.1MTransfusion Medicine/Hemostasis Clinical Trials NetworkU01HL072355 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KEY, NIGEL · 2002 to 2012
$2.1MTransfusion/Hemostasis Clinical Research NetworkU01HL072346 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SACHAIS, BRUCE · 2002 to 2012
$2.1MTMH Clinical Trials Network-Wisconsin Core Clinical CenterU01HL072290 · NHLBI · VERSITI WISCONSIN, INC. · PI MC FARLAND, JANICE G · 2002 to 2012
$2.1MNHLBI NIH HHS U01 HL072028NHLBI NIH HHS U01 HL072033NHLBI NIH HHS U01 HL072072NHLBI NIH HHS U01 HL072191NHLBI NIH HHS U01 HL072196NHLBI NIH HHS U01 HL072248NHLBI NIH HHS U01 HL072268NHLBI NIH HHS U01 HL072274NHLBI NIH HHS U01 HL072283NHLBI NIH HHS U01 HL072289NHLBI NIH HHS U01 HL072290NHLBI NIH HHS U01 HL072291NHLBI NIH HHS U01 HL072299NHLBI NIH HHS U01 HL072305NHLBI NIH HHS U01 HL072331NHLBI NIH HHS U01 HL072346NHLBI NIH HHS U01 HL072355NHLBI NIH HHS U01 HL072359
Abstract
Bleeding remains a significant problem for many thrombocytopenic hematology/oncology patients in spite of platelet transfusions. Factors that might contribute to bleeding were analyzed for 16 320 patient-days on or after their first platelet transfusion in 1077 adult patients enrolled in the Platelet Dose (PLADO) trial. All patients had a greatly increased risk of bleeding at platelet counts of ≤5 × 10
Indexed as
Erythrocyte TransfusionPlatelet TransfusionAdultBlood Coagulation TestsBlood PlateletsFemaleFibrinogenHematocritHemorrhageHumansInternational Normalized RatioMaleMiddle AgedModels, BiologicalPartial Thromboplastin TimePlatelet CountFibrinogen
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.