Evidence map›Paper›PMID 28679624›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2017

Factors regulating subcutaneous adipose tissue storage, fibrosis, and inflammation may underlie low fatty acid mobilization in insulin-sensitive obese adults.

Douglas W Van Pelt, Lisa M Guth, Abigail Y Wang, Jeffrey F Horowitz

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Douglas W Van PeltSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Lisa M GuthSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Abigail Y WangSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Jeffrey F HorowitzSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan jeffhoro@umich.edu.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Insulin sensitivity and fatty acid partitioning in skeletal muscle after exerciseR01DK077966 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOROWITZ, JEFFREY F · 2010 to 2020
$4.9M
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002240NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK077966
6 · The paper itself

Abstract

Although the rate of fatty acid release from adipose tissue into the systemic circulation is very high in most obese adults, some obese adults maintain relatively low rates of fatty acid release, which helps protect them against the development of systemic insulin resistance. The primary aim of this study was to identify factors in adipose tissue that may underlie low vs. high rates of fatty acid mobilization in a relatively homogeneous cohort of obese adults. We measured systemic fatty acid rate of appearance (FA Ra) via

Indexed as

Insulin ResistanceAdultCarbon IsotopesFatty AcidsFemaleFibrosisGlucose Clamp TechniqueGlycerol-3-Phosphate O-AcyltransferaseHumansImmunoblottingInflammationLipaseMaleMAP Kinase Signaling SystemObesitySubcutaneous Fat, AbdominalCarbon IsotopesFatty AcidsGlycerol-3-Phosphate O-AcyltransferaseLipaseadipose tissuefatty acid metabolismhealthy obesityinsulin resistance

Identifiers

PMID28679624
PMCPMC5668599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.