Evidence map›Paper›PMID 28679533›Full record

ArticleThe Journal of biological chemistry2017

A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNA

Mi Zhou, Meng Wang, Ling Xue, Zhi Lin, Qiufen He, Wenwen Shi, Yaru Chen, Xiaofen Jin, Haiying Li, Pingping Jiang and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Clinical and genetic analysis of essential hypertension with mitochondrial tRNAZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Article
  3. A snoRNA-tRNA modification network governs codon-biased cellular states.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Clinical and genetic analysis of essential hypertension withZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023
    Article
  5. The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Novel mitochondrial tRNAWorld journal of pediatrics : WJP · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. The mitochondrial tRNAExperimental and therapeutic medicine · 2019
    Article
  17. Article
  18. Noncoding RNAs in the Regulatory Network of Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018
    Review
  19. Contribution of the tRNAThe Journal of biological chemistry · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mi ZhouFrom the Division of Medical Genetics and Genomics, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China,; Institute of Genetics and Zhejiang University, Hangzhou 310058, Zhejiang, China.
Meng WangFrom the Division of Medical Genetics and Genomics, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China,; Institute of Genetics and Zhejiang University, Hangzhou 310058, Zhejiang, China.
Ling XueAttardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou 325600, Zhejiang, China.
Zhi LinAttardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou 325600, Zhejiang, China.
Qiufen HeInstitute of Genetics and Zhejiang University, Hangzhou 310058, Zhejiang, China.
Wenwen ShiAttardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou 325600, Zhejiang, China.
Yaru ChenAttardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou 325600, Zhejiang, China.
Xiaofen JinInstitute of Genetics and Zhejiang University, Hangzhou 310058, Zhejiang, China.
Haiying LiDepartment of Cardiology, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325600, Zhejiang, China.
Pingping JiangFrom the Division of Medical Genetics and Genomics, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China,; Institute of Genetics and Zhejiang University, Hangzhou 310058, Zhejiang, China.
Min-Xin GuanFrom the Division of Medical Genetics and Genomics, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China,; Institute of Genetics and Zhejiang University, Hangzhou 310058, Zhejiang, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, Zhejiang, China,; Joint Institute of Genetics and Genomic Medicine between Zhejiang University and University of Toronto, Hangzhou 310058, Zhejiang, China. Electronic address: gminxin88@zju.edu.cn.
Wenzhou Medical University · CNChildren's Hospital of Zhejiang University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several mitochondrial tRNA mutations have been associated with hypertension, but their pathophysiology remains poorly understood. In this report, we identified a novel homoplasmic 3253T→C mutation in the mitochondrial tRNA

Indexed as

Maternal InheritanceModels, MolecularMutationAdultAsian PeopleBase PairingCell LineCells, CulturedChinaDNA, MitochondrialDNA Mutational AnalysisElectrophoretic Mobility Shift AssayFemaleHumansHybrid CellsHypertensionDNA, MitochondrialReactive Oxygen SpeciesRNA, Transfer, Leuhypertensionmitochondrial diseasemitochondrial DNA (mtDNA)mitochondrial membrane potentialmitochondrial metabolismmitochondrial respiratory chain complexmutantpathogenesisRNA structuretransfer RNA (tRNA)

Identifiers

PMID28679533
PMCPMC5572913
OpenAlexW2730369721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.