Evidence map›Paper›PMID 28679528›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Moderate alcohol intake induces thermogenic brown/beige adipocyte formation

Bo Wang, Zhixiu Wang, Jeanene M de Avila, Mei-Jun Zhu, Faya Zhang, Noe Alberto Gomez, Liang Zhao, Qiyu Tian, Junxing Zhao, Joseph Maricelli and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Bo WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China.
Zhixiu WangDepartment of Animal Sciences, Washington State University, Pullman, Washington, USA.
Jeanene M de AvilaDepartment of Animal Sciences, Washington State University, Pullman, Washington, USA.
Mei-Jun ZhuSchool of Food Science, Washington State University, Pullman, Washington, USA.
Faya ZhangDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA.
Noe Alberto GomezDepartment of Animal Sciences, Washington State University, Pullman, Washington, USA.
Liang ZhaoDepartment of Animal Sciences, Washington State University, Pullman, Washington, USA.
Qiyu TianDepartment of Animal Sciences, Washington State University, Pullman, Washington, USA.
Junxing ZhaoCollege of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Shanxi, China.
Joseph MaricelliSchool of Molecular Biosciences, Washington State University, Pullman, Washington, USA.
Hui ZhangDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA.
Buel D RodgersDepartment of Animal Sciences, Washington State University, Pullman, Washington, USA.
Min DuBeijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China; min.du@wsu.edu.
Washington State University · USShanxi Agricultural University · CNChina Agricultural University · CN

Funding

Maternal obesity, AMPK and fetal brown adipogenesisR01HD067449 · NICHD · WASHINGTON STATE UNIVERSITY · PI MIN DU · 2010 to 2026
$4.6M
Zfp423 and Progenitor Adipogenesis during AgingR21AG049976 · NIA · WASHINGTON STATE UNIVERSITY · PI DU, MIN · 2016 to 2017
$405k
NIA NIH HHS R21 AG049976NICHD NIH HHS R01 HD067449
6 · The paper itself

Abstract

Clinically, low and moderate alcohol intake improves human health with protection against metabolic syndromes, including type 2 diabetes; however, mechanisms that are associated with these effects remain to be elucidated. The aims of this study were to investigate the effects of moderate alcohol intake on thermogenic brown/beige adipocyte formation and glucose and lipid homeostasis, as well as the involvement of retinoic acid (RA) signaling in the entire process. C57BL6 male mice were supplemented with 8% (w/v) alcohol in water for 1 or 4 mo. Alcohol intake prevented body weight gain, induced the formation of uncoupling protein 1-positive beige adipocytes in white adipose tissue, and increased thermogenesis in mice, which is associated with decreased serum glucose and triacylglycerol levels. Mechanistically, alcohol intake increased RA levels in serum and adipose tissue, which was associated with increased expression of aldehyde dehydrogenase family 1 subfamily A1 (

Indexed as

Adipocytes, BeigeAdipogenesisAdipose Tissue, BrownAdipose Tissue, WhiteAlcoholsDiabetes Mellitus, Type 2Diet, High-FatIon ChannelsMitochondrial ProteinsObesitySignal TransductionThermogenesisTretinoinAlcoholsIon ChannelsMitochondrial ProteinsTretinoinbeige adipocytefatty acidsglucoseobesitythermogenesis

Identifiers

PMID28679528
PMCPMC6207178
OpenAlexW2728707240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.