Evidence map›Paper›PMID 28679472›Full record

ArticleEBioMedicine2017

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin.

Paula Schiapparelli, Hugo Guerrero-Cazares, Roxana Magaña-Maldonado, Susan M Hamilla, Sara Ganaha, Eric Goulin Lippi Fernandes, Chuan-Hsiang Huang, Helim Aranda-Espinoza, Peter Devreotes, Alfredo Quinones-Hinojosa

Open access · goldAbstract read
In one paragraph

Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  8. Piezo1, the new actor in cell volume regulation.Pflugers Archiv : European journal of physiology · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Ion Channels in Gliomas-From Molecular Basis to Treatment.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Review
  17. Observational
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Paula SchiapparelliDepartment of Neurosurgery, Mayo Clinic College of Medicine, Jacksonville, FL, United States. Electronic address: Schiapparelli.paula@mayo.edu.
Hugo Guerrero-CazaresDepartment of Neurosurgery, Mayo Clinic College of Medicine, Jacksonville, FL, United States.
Roxana Magaña-MaldonadoNeuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Mexico City, Mexico.
Susan M HamillaFischell Department of Bioengineering, University of Maryland, College Park, MD, United States.
Sara GanahaDepartment of Neurosurgery, Mayo Clinic College of Medicine, Jacksonville, FL, United States.
Eric Goulin Lippi FernandesDepartment of Neurosurgery, Mayo Clinic College of Medicine, Jacksonville, FL, United States.
Chuan-Hsiang HuangDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Helim Aranda-EspinozaFischell Department of Bioengineering, University of Maryland, College Park, MD, United States.
Peter DevreotesDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Alfredo Quinones-HinojosaDepartment of Neurosurgery, Mayo Clinic College of Medicine, Jacksonville, FL, United States. Electronic address: Quinones-Hinojosa.Alfredo@mayo.edu.
Jacksonville College · USJohns Hopkins University · USUniversity of Maryland, College Park · USInstituto Nacional de Neurología y Neurocirugía · MXMayo Clinic in Florida · US

Funding

Excitable Networks in Directed Cell MigrationR35GM118177 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Peter N Devreotes · 2016 to 2026
$12.1M
Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 StimulationR01NS070024 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QUINONES-HINOJOSA, ALFREDO · 2010 to 2014
$2.4M
Role of Human Cerebrospinal Fluid Chemokines in the Invasiveness of Human GlioblastomaR21CA199295 · NCI · MAYO CLINIC JACKSONVILLE · PI GUERRERO-CAZARES, HUGO · 2016 to 2017
$384k
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. The mechanisms that confer GBM cells their invasive behavior are poorly understood. The electroneutral Na

Indexed as

Actin Depolymerizing FactorsActinsCell Line, TumorCell MovementCytoskeletonGene ExpressionGlioblastomaHumansProtein BindingProtein Transportrac1 GTP-Binding ProteinrhoA GTP-Binding ProteinSolute Carrier Family 12, Member 2Actin Depolymerizing FactorsActinsrac1 GTP-Binding ProteinrhoA GTP-Binding ProteinSolute Carrier Family 12, Member 2Actin cytoskeletonCell migrationGlioblastomaNKCC1

Identifiers

PMID28679472
PMCPMC5514434
OpenAlexW2701436143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.