SynthesisBMC public health2017
Age at first birth and risk of later-life cardiovascular disease: a systematic review of the literature, its limitation, and recommendations for future research.
Synthesis in BMC public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review.BMJ (Clinical research ed.) · 2020Pooled it
- Population attributable risk of traditional, under-recognised and female-specific factors for heart failure in women.Heart (British Cardiac Society) · 2026Article
- Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses.Cell reports. Medicine · 2025Observational
- Reproductive history, menopause and cardiometabolic health in women: a multicountry analysis.Journal of epidemiology and community health · 2025Article
- Global burden and trend of rheumatic heart disease among women of childbearing age, 1990-2021, with projection to 2040.BMC cardiovascular disorders · 2025Article
- Developmental life history transitions can be shaped by structural inequities: Insights from the sociology of race.Developmental biology · 2025Review
- Occupational Exposure to Disinfectants and Risk of Incident Cardiovascular Disease among US Nurses: The Nurses' Health Study II.Environmental health perspectives · 2025Article
- Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study.Cardiovascular diabetology · 2025Article
- Socioeconomic variations in the proportions of stroke attributable to reproductive profiles among postmenopausal women in China.BMC medicine · 2025Article
- Association of Female Reproductive Factors with Incident Cardiometabolic Disease: Finding from a European Population-Based Study.Global heart · 2025Article
- Socioeconomic disparities in the association of age at first live birth with incident stroke among Chinese parous women: A prospective cohort study.Journal of global health · 2024Article
- Reproductive factors and risk of cardiovascular diseases and all-cause and cardiovascular mortality in American women: NHANES 2003-2018.BMC women's health · 2024Article
- The contributions of fertility during adolescence to disability across the life-course: hypothesized causal pathways, research gaps, and future directions.Annals of human biology · 2024Review
- Association between number of children and incident heart disease and stroke in parents - results from the Survey of Health, Ageing and Retirement in Europe (SHARE).BMC public health · 2023Article
- The association of female reproductive factors with risk of metabolic syndrome in women from NHANES 1999-2018.BMC public health · 2023Article
- Association between age at first birth and postpartum depression: A two-sample mendelian randomization analysis.Heliyon · 2023Article
- Article
- Association of age at first birth and risk of non-alcoholic fatty liver disease in women: evidence from the NHANES.Hepatology international · 2023Article
- Coronary artery restenosis and target lesion revascularisation in women by pregnancy history.Open heart · 2023Article
- Women's reproductive traits and ischemic stroke: a two-sample Mendelian randomization study.Annals of clinical and translational neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular disease (CVD) is the principal contributor to the burden of disease and mortality worldwide. Previous studies observed associations between early age at first birth (AFB) and all-cause mortality. AFB may be associated with CVD both through physiological and sociobiological pathways. In this paper, we review the literature on AFB and CVD events and mortality. Additionally, we provide an overview of limitations of the current research and recommendations for future research.
methodsPubMed and Web of Science databases were searched for observational studies published between 1980-June 2016, investigating associations between AFB and CVD events and mortality. Data were extracted using a pre-defined list.
resultsA total of 20 publications, reporting on 33 associations, were included in the review. Ten studies observed a positive association between early AFB and CVD while two studies observed a positive association between later AFB and CVD. Substantial methodological limitations were observed related to: operationalization of exposure categories, choice of reference category, sample size, follow-up time and possibly over adjustment.
conclusionsEarly AFB is possibly related to CVD. More work, in particular from large cohort studies starting before reproductive age is reached, is needed to better investigate this relationship, and to ascertain causal pathways that may explain observed associations.
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