ArticleBMC complementary and alternative medicine2017
Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Probiotics for ulcerative colitis: mechanisms, therapeutic advances, and emerging strategies.Frontiers in microbiology · 2026Review
- The ameliorative effects of fermented Chinese herbal medicine on growth inhibition and liver damage induced by manganese exposure in largemouth bass (Micropterus salmoides).Fish physiology and biochemistry · 2025Article
- Effect of the Combination ofNutrients · 2024Article
- Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response.Genes & diseases · 2023Article
- Article
- Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice.Marine drugs · 2020Article
- Effects of Fermented Herbal Tea Residues on the Intestinal Microbiota Characteristics of Holstein Heifers Under Heat Stress.Frontiers in microbiology · 2020Article
- Anti-dermatitic effect of fermented ginseng extract including rich compound K through inhibiting activation of macrophage.Food science and biotechnology · 2019Article
- Enhanced production of compound K in fermented ginseng extracts byFood science and biotechnology · 2019Article
- Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions.Journal of animal science · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from KIOM-MA using probiotics to improve the therapeutic efficacy. We investigated whether KIOM-MA-128 has protective activity in a mouse model of acute colitis induced by dextran sodium sulfate (DSS).
methodsColitis was induced by DSS administered to ICR mice in drinking water. KIOM-MA-128 (125 or 250 mg/kg) was orally administered once per day. The body weights of the mice were measured daily, and colonic endoscopies were performed at 5 and 8 days. Colon length as well as histological and cytokine changes were observed at the end of drug administration.
resultsKIOM-MA-128 has pharmacological activity in an acute colitis model. KIOM-MA-128 reduced the loss of body weight and disease activity index (DAI) and inhibited the abnormally short colon lengths and the colonic damage in this mouse model of acute colitis. Moreover, KIOM-MA-128 suppressed pro-inflammatory cytokine expression and maintained the integrity of the tight junctions during DSS-induced colitis.
conclusionThe results indicated that KIOM-MA-128 protects against DSS-induced colitis in mice and suggested that this formula might be a candidate treatment for inflammatory bowel disease (IBD).
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