ArticleBMC genetics2017
Genome-wide association study identifies candidate genes for piglet splay leg syndrome in different populations.
Article in BMC genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach.Current issues in molecular biology · 2026Article
- Elucidation of population stratifying markers and selective sweeps in crossbred Landlly pig population using genome-wide SNP data.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Mapping and functional characterization of structural variation in 1060 pig genomes.Genome biology · 2024Article
- Selective Sweeps in the Austrian Turopolje and Other Commercial Pig Populations.Animals : an open access journal from MDPI · 2023Article
- Homer 1 genotype AA variant relates to congenital splay leg syndrome in piglets by repressing Pax7 in myogenic progenitors.Frontiers in veterinary science · 2023Article
- A questionnaire-based investigation of the swimming puppy syndrome: 115 dogs.Frontiers in veterinary science · 2023Article
- Genome-wide association study identifies SNPs for growth performance and serum indicators in Valgus-varus deformity broilers (Gallus gallus) using ddGBS sequencing.BMC genomics · 2022Article
- Runs of Homozygosity Uncover Potential Functional-Altering Mutation Associated With Body Weight and Length in Two Duroc Pig Lines.Frontiers in veterinary science · 2022Article
- Single-Step Genome Wide Association Study Identifies QTL Signals for Untrimmed and Trimmed Thigh Weight in Italian Crossbred Pigs for Dry-Cured Ham Production.Animals : an open access journal from MDPI · 2021Article
- Congenital Splay Leg Syndrome in Piglets-Current Knowledge and a New Approach to Etiology.Frontiers in veterinary science · 2021Review
- Detection of genomic regions associated malformations in newborn piglets: a machine-learning approach.PeerJ · 2021Article
- Genome-Wide Detection of Selection Signatures in Duroc Revealed Candidate Genes Relating to Growth and Meat Quality.G3 (Bethesda, Md.) · 2020Article
- Significance testing and genomic inflation factor using high-density genotypes or whole-genome sequence data.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2019Article
- Polymorphisms of HOMER1 gene are associated with piglet splay leg syndrome and one significant SNP can affect its intronic promoter activity in vitro.BMC genetics · 2018Article
- Genomic Analysis To Identify Signatures of Artificial Selection and Loci Associated with Important Economic Traits in Duroc Pigs.G3 (Bethesda, Md.) · 2018Article
- Treatment With Probiotic Bacteria Does Not Diminish the Impact of aFrontiers in veterinary science · 2018Article
- Genome-Wide Association Study Identifies Candidate Genes Related to Seed Oil Composition and Protein Content inFrontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPiglet splay leg syndrome (PSL) is one of the most frequent genetic defects, and can cause considerable economic loss in pig production. The present understanding of etiology and pathogenesis of PSL is poor. The current study focused on identifying loci associated with PSL through a genome-wide association study (GWAS) performed with the Illumina Porcine60 SNP Beadchip v2.0. The study was a case/control design with four pig populations (Duroc, Landrace, Yorkshire and one crossbred of Landrace × Yorkshire).
resultAfter quality control of the genotyping data, 185 animals (73 cases, 112 controls) and 43,495 SNPs were retained for further analysis. Principal components (PCs) identified from the genomic kinship matrix were included in the statistical model for correcting the effect of population structure. Seven chromosome-wide significant SNPs were identified on Sus scrofa chromosome 1 (SSC1), SSC2 (2 SNPs), SSC7, SSC15 (2 SNPs) and SSC16 after strict Bonferroni correction. Four genes (HOMER1 and JMY on SSC2, ITGA1 on SSC16, and RAB32 on SSC1) related to muscle development, glycogen metabolism and mitochondrial dynamics were identified as potential candidate genes for PSL.
conclusionsWe identified seven chromosome-wide significant SNPs associated with PSL and four potential candidate genes for PSL. To our knowledge, this is the first pilot study aiming to identify the loci associated with PSL using GWAS. Further investigations and validations for those findings are encouraged.
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