Evidence map›Paper›PMID 28678802›Full record

ArticlePloS one2017

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression.

Lei Zhang, Xiaorui Liu, Junze Liu, Zhanqin Zhou, Yuxuan Song, Binyun Cao, Xiaopeng An

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Effects ofEvidence-based complementary and alternative medicine : eCAM · 2020
    Article
  13. Pleiotrophin: Activity and mechanism.Advances in clinical chemistry · 2020
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lei ZhangCollege of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.
Xiaorui LiuCollege of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.
Junze LiuCollege of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.
Zhanqin ZhouCollege of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.
Yuxuan SongCollege of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.
Binyun CaoCollege of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.ORCID http://orcid.org/0000-0002-9649-3246
Xiaopeng AnCollege of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.
Northwest A&F University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence has shown that miRNAs play important roles in endometrium development during the menstrual cycle in humans and many other animals. Our previous data indicated that miR-182 levels increase 15.55-fold and pleiotrophin (PTN) levels decrease 20.97-fold in the receptive endometrium (RE, D15) compared with the pre-receptive endometrium (PE, D5) in dairy goats. The present study shows that miR-182 is widely expressed in different tissues of dairy goats and that its expression levels are regulated by E2 and P4 in endometrial epithelium cells (EECs). We confirmed that PTN is a target of miR-182 and that miR-182 regulates the protein levels of AKT, Bcl-2, FAS, MAPK, Caspase-3 and SP1 in EECs. Furthermore, miR-182 up-regulates or maintains the expression levels of osteopontin (OPN), cyclooxygenase-2 (COX-2) and prolactin receptor (PRLR) in EECs, suggesting that miR-182 is an important regulatory factor in the construction of endometrial receptivity in dairy goats. In conclusion, miR-182 participates in the development of endometrial receptivity by down-regulating PTN and affecting the expression of select apoptosis-related genes and increasing or maintaining the expression levels of OPN, COX-2 and PRLR in the EECs of dairy goats.

Indexed as

3' Untranslated RegionsAnimalsApoptosisBase SequenceBinding SitesCarrier ProteinsCell ProliferationCells, CulturedCytokinesDown-RegulationEndometriumEndothelial CellsEstradiolEstrous CycleFemaleGene Expression3' Untranslated RegionsCarrier ProteinsCytokinesEstradiolMicroRNAspleiotrophinProgesteroneProto-Oncogene Proteins c-akt

Identifiers

PMID28678802
PMCPMC5497977
OpenAlexW2727967845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.