ArticleNature2017
Nutrient sensing modulates malaria parasite virulence.
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
102 citing papers in PubMed, 190 citations in OpenAlex.
- Article
- Longitudinal plasma metabolomics reveals a role for taurine in asymptomatic malaria and seasonal persistence.Nature microbiology · 2026Article
- Dual interference with host neuropeptide signaling allows parasitoid wasp to hijack host sugar metabolism.The EMBO journal · 2026Article
- Inhibition of Wnt signaling in primary human hepatocytes promotes Plasmodium falciparum liver stage development.PLoS pathogens · 2025Article
- Histone lactylation: A new epigenetic mark in the malaria parasite Plasmodium.PLoS genetics · 2025Article
- Unusual replication dynamics during Plasmodium falciparum schizogony.Malaria journal · 2025Review
- Evolutionary Trajectory ofBiomedicines · 2025Review
- Application of Multiplatform Mass Spectrometry to the Study ofInternational journal of molecular sciences · 2025Article
- A ketogenic diet halts malaria parasite growth.Nature metabolism · 2025Article
- β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice.Nature metabolism · 2025Article
- SIP2 is the master transcription factor ofScience advances · 2025Article
- Immune regulation of host energy metabolism and periodicity of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- The microbiota, the malarial parasite, and the mice-a three-sided relationship.Frontiers in microbiology · 2025Review
- Baculoviruses manipulate host lipid metabolism via adipokinetic hormone signaling to induce climbing behavior.PLoS pathogens · 2025Article
- Infection length and host environment influence on Plasmodium falciparum dry season reservoir.EMBO molecular medicine · 2024Article
- RNA polymerase III is involved in regulatingeLife · 2024Article
- The α subunit of AMP-activated protein kinase is critical for the metabolic success and tachyzoite proliferation of Toxoplasma gondii.Microbial biotechnology · 2024Article
- The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024Review
- PfEMP1 and var genes - Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity.Advances in parasitology · 2024Review
- Iron transport pathways in the human malaria parasiteFrontiers in cellular and infection microbiology · 2024Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 4 countries.
Funding
Abstract
The lifestyle of intracellular pathogens, such as malaria parasites, is intimately connected to that of their host, primarily for nutrient supply. Nutrients act not only as primary sources of energy but also as regulators of gene expression, metabolism and growth, through various signalling networks that enable cells to sense and adapt to varying environmental conditions. Canonical nutrient-sensing pathways are presumed to be absent from the causative agent of malaria, Plasmodium, thus raising the question of whether these parasites can sense and cope with fluctuations in host nutrient levels. Here we show that Plasmodium blood-stage parasites actively respond to host dietary calorie alterations through rearrangement of their transcriptome accompanied by substantial adjustment of their multiplication rate. A kinome analysis combined with chemical and genetic approaches identified KIN as a critical regulator that mediates sensing of nutrients and controls a transcriptional response to the host nutritional status. KIN shares homology with SNF1/AMPKα, and yeast complementation studies suggest that it is part of a functionally conserved cellular energy-sensing pathway. Overall, these findings reveal a key parasite nutrient-sensing mechanism that is critical for modulating parasite replication and virulence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.