ArticleNature2017
Crystal structures of agonist-bound human cannabinoid receptor CB
RetractedOpen access · greenAbstract readRetracted Publication
In one paragraph
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 230 papers.
0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed
42.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
230 citing papers in PubMed, 501 citations in OpenAlex.
- Article
- Article
- Dynamic mechanism for subtype selectivity of endocannabinoids.The Journal of biological chemistry · 2026Article
- Cannabinoid-based Pharmacology for the Management of Substance Use Disorders.Current topics in behavioral neurosciences · 2026Review
- Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026Review
- Exceptionally Potent Chiral Anandamide Analogs.Journal of medicinal chemistry · 2025Article
- Type-1 Cannabinoid Receptor Promiscuous Coupling: Computational Insights into Receptor-G Protein Interaction Dynamics.International journal of molecular sciences · 2025Article
- Outsmarting generic legislation: 4 years into the cat-and-mouse game of the synthetic cannabinoid receptor agonist market since the Chinese ban in 2021.Archives of toxicology · 2025Review
- Article
- Effects of Membrane Cholesterol on the Structure and Function of Selected Class A GPCRs─Challenges and Future Perspectives.Biochemistry · 2025Review
- Evaluation of the Cytotoxic Activity of Nanostructured Lipid Carrier Systems for Fatty Acid Amides and Silk Fibroins in Breast Cancer Cell Lines.Molecules (Basel, Switzerland) · 2025Article
- Synthesis of New N,N'-Diarylureas and Their Theoretical Study as Cannabinoid-1 Receptor Inhibitors.ChemPlusChem · 2025Article
- Molecular Mechanisms of the Endocannabinoid System with a Focus on Reproductive Physiology and the Cannabinoid Impact on Fertility.International journal of molecular sciences · 2025Review
- How THC works: Explaining ligand affinity for, and partial agonism of, cannabinoid receptor 1.iScience · 2025Article
- Novel Tetraolefinic Chain Phenyl Substituted Endocannabinoid Probes.Journal of medicinal chemistry · 2025Article
- Dysregulation of the Cannabinoid System in Childhood Epilepsy: From Mechanisms to Therapy.International journal of molecular sciences · 2025Review
- Synthesis and Pharmacological Characterization of a Novel Cannabinoid Receptor 1 Antagonist.ACS omega · 2025Article
- Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery.Acta pharmacologica Sinica · 2025Review
- Development of Squaramides as Allosteric Modulators of the CBJournal of medicinal chemistry · 2025Article
- Bayesian Nonparametric Analysis of Residence Times for Protein-Lipid Interactions in Molecular Dynamics Simulations.Journal of chemical theory and computation · 2025Article
170 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2025-08-27Concerns/Issues about Data · Retract and Replace · · see https://www.nature.com/articles/s41586-025-09454-5
- Retracted
Authors and funding
20 authors at 6 institutions in 2 countries.
Tian HuaiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Kiran VemuriCenter for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Spyros P NikasCenter for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Robert B LaprairieDepartments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
Yiran WuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Lu QuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Mengchen PuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Anisha KordeCenter for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Shan JiangCenter for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Jo-Hao HoDepartments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
Gye Won HanDepartments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA.
Kang DingiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Xuanxuan LiComplex Systems Division, Beijing Computational Science Research Center, Beijing 100193, China.
Haiguang LiuComplex Systems Division, Beijing Computational Science Research Center, Beijing 100193, China.
Michael A HansonGPCR Consortium, San Marcos, California 92078, USA.
Suwen ZhaoiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Laura M BohnDepartments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
Alexandros MakriyannisCenter for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Raymond C StevensiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Zhi-Jie LiuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
ShanghaiTech University · CNInstitute of Biophysics · CNScripps Research Institute · USBeijing Computational Science Research Center · CNUniversity of Southern California · USClinical Research Consortium · US
Funding
Project 3 - In vivo pharmacology of cannabinoid receptor probesP01DA009158 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Alexandros Makriyannis · 1994 to 2026
$26.0MCannabinergic Medications for Methamphetamine AddictionR37DA023142 · NIDA · NORTHEASTERN UNIVERSITY · PI MAKRIYANNIS, ALEXANDROS · 2007 to 2016
$7.1MStructure and Function of CB2 ReceptorR01DA045020 · NIDA · NORTHEASTERN UNIVERSITY · PI BOHN, LAURA M., KATRITCH, VSEVOLOD · 2017 to 2021
$3.9MStructure Function of CB1 Cannabinoid ReceptorR01DA041435 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KATRITCH, VSEVOLOD, MAKRIYANNIS, ALEXANDROS · 2016 to 2020
$3.6MRational discovery of new DOR chemotypes to prevent addiction and overdoseR21DA038858 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KATRITCH, VSEVOLOD · 2015 to 2016
$410kRational Anthrax Vaccine with Structural Epitopes on VLPR43AI052969 · NIAID · PLEXUS VACCINE · PI KATRITCH, VSEVOLOD · 2002 to 2002
$98kNIAID NIH HHS R43 AI052969NIDA NIH HHS P01 DA009158NIDA NIH HHS R01 DA041435NIDA NIH HHS R01 DA045020NIDA NIH HHS R21 DA038858NIDA NIH HHS R37 DA023142
Abstract
The cannabinoid receptor 1 (CB
Indexed as
Binding SitesCannabinoid Receptor AgonistsCrystallography, X-RayDronabinolDroperidolHeterotrimeric GTP-Binding ProteinsHumansLigandsMolecular Docking SimulationProtein BindingProtein ConformationReceptor, Cannabinoid, CB17'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinolAM11542Cannabinoid Receptor AgonistsDronabinolDroperidolHeterotrimeric GTP-Binding ProteinsLigandsReceptor, Cannabinoid, CB1
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.