ArticleRadiology2017
Temporal Subtraction of Serial CT Images with Large Deformation Diffeomorphic Metric Mapping in the Identification of Bone Metastases.
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Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A Systematic Review on the Use of Registration-Based Change Tracking Methods in Longitudinal Radiological Images.Journal of imaging informatics in medicine · 2025Pooled it
- Unsupervised anomaly detection for longitudinal comparison in whole-body PET/CT images.International journal of computer assisted radiology and surgery · 2026Article
- Artificial intelligence-aided lytic spinal bone metastasis classification on CT scans.International journal of computer assisted radiology and surgery · 2023Article
- The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva.Tomography (Ann Arbor, Mich.) · 2023Article
- Preoperative prediction for mastoid extension of middle ear cholesteatoma using temporal subtraction serial HRCT studies.European radiology · 2022Article
- Improved assessment of middle ear recurrent/residual cholesteatomas using temporal subtraction CT.Japanese journal of radiology · 2022Article
- SL-HarDNet: Skin lesion segmentation with HarDNet.Frontiers in bioengineering and biotechnology · 2022Article
- Temporal subtraction CT with nonrigid image registration improves detection of bone metastases by radiologists: results of a large-scale observer study.Scientific reports · 2021Article
- CT temporal subtraction: techniques and clinical applications.Quantitative imaging in medicine and surgery · 2021Article
- Consecutive Serial Non-Contrast CT Scan-Based Deep Learning Model Facilitates the Prediction of Tumor Invasiveness of Ground-Glass Nodules.Frontiers in oncology · 2021Article
- Rapid study assessment in follow-up whole-body computed tomography in patients with multiple myeloma using a dedicated bone subtraction software.European radiology · 2020Article
- Temporal subtraction of computed tomography images improves detectability of bone metastases by radiology residents.European radiology · 2019Article
- CT temporal subtraction improves early detection of bone metastases compared to SPECT.European radiology · 2019Article
- Detection of suspected brain infarctions on CT can be significantly improved with temporal subtraction images.European radiology · 2019Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Ryo SakamotoFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Masahiro YakamiFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Koji FujimotoFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Keita NakagomiFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Takeshi KuboFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Yutaka EmotoFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Thai AkasakaFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Gakuto AoyamaFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Hiroyuki YamamotoFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Michael I MillerFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Susumu MoriFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Kaori TogashiFrom the Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (R.S., M.Y., K.F., T.K., T.A., K.T.); Advanced Information & Real-world Technology Development Center 1, Canon, Kyoto, Japan (K.N., G.A., H.Y.); Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan (K.N., G.A., H.Y.); Department of Medical Science, Kyoto College of Medical Science, Oyama-Higashimachi, Sonobe-cho, Nantan, Kyoto, Japan (Y.E.); Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.); Center for Imaging Science, Johns Hopkins University, Baltimore, Md (M.I.M.); Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Md (S.M.); and F.M. Kirby Functional Imaging Center, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Md (S.M.).
Kyoto University · JPKyoto University Hospital · JPCanon (Japan) · JPImaging Center · USJohns Hopkins University · USKyoto College of Medical Science · JP
Funding
Continued Development and Maintenance of MriStudioR01NS084957 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MORI, SUSUMU · 2013 to 2022
$3.6MNINDS NIH HHS R01 NS084957
Abstract
Purpose To determine the improvement of radiologist efficiency and performance in the detection of bone metastases at serial follow-up computed tomography (CT) by using a temporal subtraction (TS) technique based on an advanced nonrigid image registration algorithm. Materials and Methods This retrospective study was approved by the institutional review board, and informed consent was waived. CT image pairs (previous and current scans of the torso) in 60 patients with cancer (primary lesion location: prostate, n = 14; breast, n = 16; lung, n = 20; liver, n = 10) were included. These consisted of 30 positive cases with a total of 65 bone metastases depicted only on current images and confirmed by two radiologists who had access to additional imaging examinations and clinical courses and 30 matched negative control cases (no bone metastases). Previous CT images were semiautomatically registered to current CT images by the algorithm, and TS images were created. Seven radiologists independently interpreted CT image pairs to identify newly developed bone metastases without and with TS images with an interval of at least 30 days. Jackknife free-response receiver operating characteristics (JAFROC) analysis was conducted to assess observer performance. Reading time was recorded, and usefulness was evaluated with subjective scores of 1-5, with 5 being extremely useful and 1 being useless. Significance of these values was tested with the Wilcoxon signed-rank test. Results The subtraction images depicted various types of bone metastases (osteolytic, n = 28; osteoblastic, n = 26; mixed osteolytic and blastic, n = 11) as temporal changes. The average reading time was significantly reduced (384.3 vs 286.8 seconds; Wilcoxon signed rank test, P = .028). The average figure-of-merit value increased from 0.758 to 0.835; however, this difference was not significant (JAFROC analysis, P = .092). The subjective usefulness survey response showed a median score of 5 for use of the technique (range, 3-5). Conclusion TS images obtained from serial CT scans using nonrigid registration successfully depicted newly developed bone metastases and showed promise for their efficient detection.
Indexed as
Subtraction TechniqueAgedAged, 80 and overBone NeoplasmsBreast NeoplasmsFemaleHumansLung NeoplasmsMaleMiddle AgedRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesTomography, X-Ray Computed
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