ArticleDevelopmental psychobiology2017
Exposure to chronic variable social stress during adolescence alters affect-related behaviors and adrenocortical activity in adult male and female inbred mice.
Article in Developmental psychobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Enduring sex-dependent implications of pubertal stress on the gut-brain axis and mental health.Frontiers in behavioral neuroscience · 2023Review
- An ecological animal model of subthreshold depression in adolescence: behavioral and resting stateTranslational psychiatry · 2022Article
- The impact of adolescent stress on nicotine use and affective disorders in rodent models.The European journal of neuroscience · 2022Review
- Sex- and age-dependent effects of chronic corticosterone exposure on depressive-like, anxiety-like, and fear-related behavior: Role of amygdala glutamate receptors in the rat.Frontiers in behavioral neuroscience · 2022Article
- Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals.Neuroscience and behavioral physiology · 2022Article
- Developmental stress has sex-specific effects on contextual and cued fear conditioning in adulthood.Physiology & behavior · 2021Article
- Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice.Journal of neuroimmunology · 2021Article
- Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice.Frontiers in behavioral neuroscience · 2021Article
- Chronic psychological stress during adolescence induces sex-dependent adulthood inflammation, increased adiposity, and abnormal behaviors that are ameliorated by selective inhibition of soluble tumor necrosis factor with XPro1595.Brain, behavior, and immunity · 2019Article
- Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading.Frontiers in physiology · 2019Article
- Chronic stress dysregulates amygdalar output to the prefrontal cortex.Neuropharmacology · 2018Article
- Adolescent social stress increases anxiety-like behavior and ethanol consumption in adult male and female C57BL/6J mice.Scientific reports · 2018Article
- Adolescent chronic variable social stress influences exploratory behavior and nicotine responses in male, but not female, BALB/cJ mice.Brain research bulletin · 2018Article
- Adolescent Social Stress Increases Anxiety-like Behavior and Alters Synaptic Transmission, Without Influencing Nicotine Responses, in a Sex-Dependent Manner.Neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rodent models provide valuable insight into mechanisms that underlie vulnerability to adverse effects of early-life challenges. Few studies have evaluated sex differences in anxiogenic or depressogenic effects of adolescent social stress in a rodent model. Furthermore, adolescent stress studies often use genetically heterogeneous outbred rodents which can lead to variable results. The current study evaluated the effects of adolescent social stress in male and female inbred (BALB/cJ) mice. Adolescent mice were exposed to repeat cycles of alternating social isolation and social novelty for 4 weeks. Adolescent social stress increased anxiety-related behaviors in both sexes and depression-related behavior in females. Locomotion/exploratory behavior was also decreased in both sexes by stress. Previously stressed adult mice produced less basal fecal corticosteroids than controls. Overall, the novel protocol induced sex-specific changes in anxiety- and depression-related behaviors and corticoid production in inbred mice. The chronic variable social stress protocol used here may be beneficial to systematically investigate sex-specific neurobiological mechanisms underlying adolescent stress vulnerability where genetic background can be controlled.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.