ArticleThe Journal of physiology2018
Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 99 citations in OpenAlex.
- Molecular changes in hypoxia-induced central neural circuits and nuclei.Medical gas research · 2026Review
- G Protein-Coupled Receptor in High-Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities.MedComm · 2026Review
- Review
- ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration.Neurochemical research · 2025Review
- Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex.CNS neuroscience & therapeutics · 2025Article
- Development and characterization of an autoresuscitation test for preclinical SUDEP models.Epilepsia · 2025Article
- Respiratory and Metabolic Effects of Active Expiration in Freely Behaving Rats.Acta physiologica (Oxford, England) · 2025Article
- Intrinsic responses to hypoxia and hypercapnia of neurons in the cardiorespiratory center of the ventral medulla of newborn rats.Pflugers Archiv : European journal of physiology · 2025Article
- Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping.Journal of neurophysiology · 2024Article
- Review
- Hypoxia sensing in the body: An update on the peripheral and central mechanisms.Experimental physiology · 2024Review
- Brainstem astrocytes regulate breathing and may affect arousal state in rats.Physiology & behavior · 2024Article
- Contributions of carotid bodies, retrotrapezoid nucleus neurons and preBötzinger complex astrocytes to the COThe Journal of physiology · 2024Article
- Brainstem astrocytes regulate breathing and may affect arousal state in rats.bioRxiv : the preprint server for biology · 2023Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- A Review of Research on the Association between Neuron-Astrocyte Signaling Processes and Depressive Symptoms.International journal of molecular sciences · 2023Review
- Purinergic signaling: a potential therapeutic target for depression and chronic pain.Purinergic signalling · 2023Review
- Minocycline prevents hypoxia-induced seizures.Frontiers in neural circuits · 2023Article
- The endocannabinoid system and breathing.Frontiers in neuroscience · 2023Review
- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
key pointsThe ventilatory response to reduced oxygen (hypoxia) is biphasic, comprising an initial increase in ventilation followed by a secondary depression. Our findings indicate that, during hypoxia, astrocytes in the pre-Bötzinger complex (preBötC), a critical site of inspiratory rhythm generation, release a gliotransmitter that acts via P2Y ABSTRACT: The hypoxic ventilatory response (HVR) is biphasic, consisting of a phase I increase in ventilation followed by a secondary depression (to a steady-state phase II) that can be life-threatening in premature infants who suffer from frequent apnoeas and respiratory depression. ATP released in the ventrolateral medulla oblongata during hypoxia attenuates the secondary depression. We explored a working hypothesis that vesicular release of ATP by astrocytes in the pre-Bötzinger Complex (preBötC) inspiratory rhythm-generating network acts via P2Y
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.