Evidence map›Paper›PMID 28678345›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial.

Karen C Johnson, George A Bray, Lawrence J Cheskin, Jeanne M Clark, Caitlin M Egan, John P Foreyt, Katelyn R Garcia, Stephen Glasser, Frank L Greenway, Edward W Gregg and 27 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 6 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 6 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Reporting and Analyzing Race and Ethnicity in Orthopaedic Clinical Trials: A Systematic Review.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2021
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  7. Trial
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  14. Effect of Aerobic or Resistance Exercise, or Both, on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
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  18. Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
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  19. Review
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 2 countries.

Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
George A BrayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Lawrence J CheskinJohns Hopkins University, Baltimore, MD, USA.
Jeanne M ClarkJohns Hopkins University, Baltimore, MD, USA.
Caitlin M EganWeight Control and Diabetes Research Center, Providence, RI, USA.
John P ForeytBaylor College of Medicine, Houston, TX.
Katelyn R GarciaWake Forest School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Stephen GlasserUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Frank L GreenwayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Edward W GreggCenters for Disease Control and Prevention, Atlanta, GA, USA.
Helen P HazudaThe University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Andrea HergenroederUniversity of Pittsburgh, Pittsburgh, PA, USA.
James O HillUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Edward S HortonJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
John M JakicicUniversity of Pittsburgh, Pittsburgh, PA, USA.
Robert W JefferyUniversity of Minnesota, Minneapolis, MN, USA.
Steven E KahnVA Puget Sound Health Care System, University of Washington, Seattle, WA, USA.
William C KnowlerSouthwestern American Indian Center, Phoenix, AZ, USA.
Cora E LewisUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Marsha MillerUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Maria G MontezThe University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
David M NathanMassachusetts General Hospital, Harvard University, Boston, MA, USA.
Jennifer L PatricioSt. Luke's Roosevelt Hospital Center, Columbia University, New York, NY, USA.
Anne L PetersUniversity of Southern California, Los Angeles, CA, USA.
Xavier Pi-SunyerColumbia University Medical Center, New York, NY, USA.
Henry J PownallHouston Methodist Research Institute, Houston, TX, USA.
David ReboussinWake Forest School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
J Bruce RedmonUniversity of Minnesota, Minneapolis, MN, USA.
Helmut SteinbergDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Thomas A WaddenUniversity of Pennsylvania, Philadelphia, PA, USA.
Lynne E WagenknechtWake Forest School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Rena R WingThe Miriam Hospital/Brown Medical School, Brown University, Providence, RI, USA.
Catherine R WomackDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Susan Z YanovskiNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
Ping ZhangCenters for Disease Control and Prevention, Atlanta, GA, USA.
Ann V SchwartzUniversity of California, San Francisco, San Francisco, CA, USA.
Look AHEAD Study Group
University of Tennessee Health Science Center · USWake Forest University · USCenters for Disease Control and Prevention · USJohns Hopkins University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Alabama at Birmingham · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Minnesota System · USUniversity of Pittsburgh · USAmerican Indian Center · USBaylor College of Medicine · USBrown University · USColumbia University · USColumbia University Irving Medical Center · USHouston Methodist · USJoslin Diabetes Center · USLouisiana State University · USMassachusetts General Hospital · USNational Institute of Diabetes and Digestive and Kidney Diseases · USPennington Biomedical Research Center · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
Look AHEAD: Action for Health in DiabetesU01DK057136 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW, WAGENKNECHT, LYNNE E · 1999 to 2020
$54.9M
ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI ALBERT, RICHARD K · 1985 to 2008
$52.6M
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 1985 to 2008
$37.4M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
ZOLEDRONATE VS AREDIA IN MULTIPLE MYELOMA/BREAST CANCER W /BONE DISORDERSM01RR001346 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ESCAMILLA, MICHAEL A · 1985 to 2008
$23.1M
NCRR NIH HHS M01 RR000051NCRR NIH HHS M01 RR000056NCRR NIH HHS M01 RR001066NCRR NIH HHS M01 RR001346NCRR NIH HHS M01 RR002719NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1 RR025758NIA NIH HHS P30 AG024827NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK046204NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK079626NIDDK NIH HHS U01 DK056990NIDDK NIH HHS U01 DK056992NIDDK NIH HHS U01 DK057002NIDDK NIH HHS U01 DK057008NIDDK NIH HHS U01 DK057078NIDDK NIH HHS U01 DK057131NIDDK NIH HHS U01 DK057135NIDDK NIH HHS U01 DK057136NIDDK NIH HHS U01 DK057149NIDDK NIH HHS U01 DK057151NIDDK NIH HHS U01 DK057154NIDDK NIH HHS U01 DK057171NIDDK NIH HHS U01 DK057177NIDDK NIH HHS U01 DK057178NIDDK NIH HHS U01 DK057182NIDDK NIH HHS U01 DK057219
6 · The paper itself

Abstract

Intentional weight loss is an important treatment option for overweight persons with type 2 diabetes mellitus (DM), but the effects on long-term fracture risk are not known. The purpose of this Look AHEAD analysis was to evaluate whether long-term intentional weight loss would increase fracture risk in overweight or obese persons with DM. Look AHEAD is a multicenter, randomized clinical trial. Recruitment began in August 2001 and follow-up continued for a median of 11.3 years at 16 academic centers. A total of 5145 persons aged 45 to 76 years with DM were randomized to either an intensive lifestyle intervention (ILI) with reduced calorie consumption and increased physical activity designed to achieve and maintain ≥7% weight loss or to diabetes support and education intervention (DSE). Incident fractures were ascertained every 6 months by self-report and confirmed with central adjudication of medical records. The baseline mean age of participants was 59 years, 60% were women, 63% were white, and the mean BMI was 36 kg/m

Indexed as

Weight LossDiabetes Mellitus, Type 2FemaleFractures, BoneHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRisk FactorsCLINICAL TRIALFRACTUREINTENTIONAL WEIGHT LOSSTYPE 2 DIABETES

Identifiers

PMID28678345
PMCPMC5685890
OpenAlexW2727111851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.