Evidence map›Paper›PMID 28678158›Full record

ArticleInternational journal of molecular sciences2017

Early Hippocampal i-LTP and LOX-1 Overexpression Induced by Anoxia: A Potential Role in Neurodegeneration in NPC Mouse Model.

Adriana Lo Castro, Michela Murdocca, Sabina Pucci, Anna Zaratti, Chiara Greggi, Federica Sangiuolo, Virginia Tancredi, Claudio Frank, Giovanna D'Arcangelo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Organ Weights inInternational journal of molecular sciences · 2022
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Adriana Lo CastroDepartment of Medical System, University of Rome Tor Vergata, Rome 00133, Italy. a.locastro@libero.it.
Michela MurdoccaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome 00133, Italy. miky.murdi@hotmail.it.
Sabina PucciDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome 00133, Italy. sabinapuc@yahoo.it.
Anna ZarattiCNMR, Istituto Superiore di Sanità Roma, Rome 00161, Italy. anna.zaratti1983@libero.it.
Chiara GreggiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome 00133, Italy. chiaragreggi@gmail.com.
Federica SangiuoloDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome 00133, Italy. sangiuolo@med.uniroma2.it.
Virginia TancrediDepartment of Medical System, University of Rome Tor Vergata, Rome 00133, Italy. tancredi@uniroma2.it.
Claudio FrankCNMR, Istituto Superiore di Sanità Roma, Rome 00161, Italy. claudio.frank@iss.it.
Giovanna D'ArcangeloDepartment of Medical System, University of Rome Tor Vergata, Rome 00133, Italy. giovanna.darcangelo@uniroma2.it.
University of Rome Tor Vergata · ITIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann-Pick type C disease (NPCD) is an autosomal recessive storage disorder, characterized by abnormal sequestration of unesterified cholesterol within the late endo-lysosomal compartment of cells. In the central nervous system, hypoxic insults could result in low-density lipoprotein (LDL) oxidation and Lectin-like oxidized LDL receptor-1 (LOX-1) induction, leading to a pathological hippocampal response, namely, ischemic long-term potentiation (i-LTP). These events may correlate with the progressive neural loss observed in NPCD. To test these hypotheses, hippocampal slices from Wild Type (WT) and

Indexed as

Long-Term PotentiationAnimalsDisease Models, AnimalGene ExpressionGlucoseHippocampusHypoxia-Ischemia, BrainImmunohistochemistryMiceMice, KnockoutNiemann-Pick Disease, Type COxidative StressOxygenScavenger Receptors, Class EGlucoseOlr1 protein, mouseOxygenScavenger Receptors, Class Ei-LTPLOX-1neurodegenerationNPCD

Identifiers

PMID28678158
PMCPMC5535933
OpenAlexW2728246728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.