ArticleAnnals of surgery2017
Failure to Diagnose Hyperparathyroidism in 10,432 Patients With Hypercalcemia: Opportunities for System-level Intervention to Increase Surgical Referrals and Cure.
Article in Annals of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 91 citations in OpenAlex.
- Does Parathyroid Autotransplantation Prevent Hypoparathyroidism After Thyroid Surgery?Annals of surgery · 2026Article
- Patient-Reported Outcome Measures Used in Primary Hyperparathyroidism: A Scoping Review.Annals of surgical oncology · 2026Article
- Clinical and epidemiologic characteristics of hospitalized oncological patients with hypercalcemia: a longitudinal, multicenter study.Wiener medizinische Wochenschrift (1946) · 2026Observational
- Recurrent pathological fractures in chronic kidney disease revealing overlapping neglected primary hyperparathyroidism and GDF5-associated skeletal dysplasia.Archives of osteoporosis · 2025Article
- A Lost Opportunity: Early Nephrolithiasis as a Missed Indicator of Primary Hyperparathyroidism Over Eight Years.Clinical case reports · 2025Article
- The Landmark Series: Management of Primary Hyperparathyroidism.Annals of surgical oncology · 2025Review
- Opportunistic Assessment for Parathyroid Adenoma on CT: A Retrospective Cohort Study Evaluating Primary Hyperparathyroidism-Associated Morbidity Over 10 Years of Follow-Up.AJR. American journal of roentgenology · 2025Article
- Patient Neighborhood Adversity Associated With Access Not Wait Time to Parathyroidectomy.The Journal of surgical research · 2024Article
- Results of a novel intervention to increase rates of diagnosis and treatment of primary hyperparathyroidism.American journal of surgery · 2024Article
- Opportunities to improve the diagnosis and treatment of primary hyperparathyroidism: retrospective cohort study.Gland surgery · 2024Article
- Patient Characteristics, Management, and Outcomes in a Novel Cohort of Primary Hyperparathyroidism.Journal of the Endocrine Society · 2024Article
- Thresholds for surgical referral in primary hyperparathyroidism: A conjoint analysis.American journal of surgery · 2023Article
- Association between hysterectomy and kidney stone disease: results from the National Health and Nutrition Examination Survey 2007-2018 and Mendelian randomization analysis.World journal of urology · 2023Observational
- A Therapeutic Approach to Primary Hyperparathyroidism: A Collaborative Evaluation Between Endocrinology and Surgery.Cureus · 2023Article
- Analysis of Time to Diagnosis and Outcomes Among Adults With Primary Hyperparathyroidism.JAMA network open · 2022Article
- Screening for Primary Aldosteronism is Underutilized in Patients with Obstructive Sleep Apnea.The American journal of medicine · 2022Article
- Use and disparities in parathyroidectomy for symptomatic primary hyperparathyroidism in the Medicare population.Surgery · 2021Article
- Association of symptomatic gallstones and primary hyperparathyroidism: a propensity score-matched analysis.The British journal of surgery · 2021Article
- Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients.Clinical medicine insights. Endocrinology and diabetes · 2021Article
- ASO Author Reflections: Race and Gender Disparities in Access to Parathyroidectomy: A Need to Change Processes for Diagnosis and Referral to Surgeons.Annals of surgical oncology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether a significant number of patients with hyperparathyroidism remain undiagnosed and untreated.
backgroundFailure to diagnose primary hyperparathyroidism and refer patients to surgeons leads to impaired quality of life and increased costs. We hypothesized that many patients with hyperparathyroidism would be untreated due to not considering the diagnosis, inadequate evaluation of hypercalcemia, and under-referral to surgeons.
methodsWe reviewed administrative data on 682,704 patients from a tertiary referral center between 2011 and 2015, and identified hypercalcemia (>10.5 mg/dL) in 10,432 patients. We evaluated whether hypercalcemic patients underwent measurement of parathyroid hormone (PTH), had documentation of hypercalcemia/hyperparathyroidism, or were referred to surgeons.
resultsThe mean age of our cohort was 54 years, with 61% females, and 56% whites. Only 3200 (31%) hypercalcemic patients had PTH levels measured, 2914 (28%) had a documented diagnosis of hypercalcemia, and 880 (8%) had a diagnosis of hyperparathyroidism in the medical record. Only 592 (22%) out of 2666 patients with classic hyperparathyroidism (abnormal calcium and PTH) were referred to surgeons.
conclusionsA significant proportion of patients with hyperparathyroidism do not undergo appropriate evaluation and surgical referral. System-level interventions which prompt further evaluation of hypercalcemia and raise physician awareness about hyperparathyroidism could improve outcomes and produce long-term cost savings.
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