Evidence map›Paper›PMID 28677711›Full record

ArticleChemical communications (Cambridge, England)2017

A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior.

NIcholas T Jacob, Kensaku Anraku, Atsushi Kimishima, Bin Zhou, Karen C Collins, Jonathan W Lockner, Beverley A Ellis, Kim D Janda

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 3 countries.

NIcholas T JacobDepartment of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA. kdjanda@scripps.edu.
Kensaku Anraku
Atsushi Kimishima
Bin Zhou
Karen C Collins
Jonathan W Lockner
Beverley A Ellis
Kim D Janda
Scripps Research Institute · US

Funding

Scripps Translational Science InstituteUL1TR001114 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2013 to 2017
$24.0M
Immunopharmacotherapy for the Treatment of Cocaine AbuseR01DA008590 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 1994 to 2016
$6.4M
NCATS NIH HHS UL1 TR001114NIDA NIH HHS R01 DA008590
6 · The paper itself

Abstract

A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg

Indexed as

AnimalsAntibodiesCocaineDisaccharidesDose-Response Relationship, DrugLocomotionMiceMolecular ConformationAntibodiesCocaineDisaccharidesgalactosyl-(1-3)galactose

Identifiers

PMID28677711
PMCPMC5559285
OpenAlexW2641237337

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.