Evidence map›Paper›PMID 28677525›Full record

ArticleeLife2017

An intersectional gene regulatory strategy defines subclass diversity of

Paschalis Kratsios, Sze Yen Kerk, Catarina Catela, Joseph Liang, Berta Vidal, Emily A Bayer, Weidong Feng, Estanisla Daniel De La Cruz, Laura Croci, G Giacomo Consalez and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  9. TheiScience · 2025
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  12. Almost 40 years of studying homeobox genes in C. elegans.Development (Cambridge, England) · 2024
    Article
  13. Review
  14. Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  15. Article
  16. Review
  17. A molecular atlas of adultbioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Transcriptome age of individual cell types inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Paschalis KratsiosDepartment of Neurobiology, University of Chicago, Chicago, United States.ORCID 0000-0002-1363-9271
Sze Yen KerkDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Catarina CatelaDepartment of Neurobiology, University of Chicago, Chicago, United States.
Joseph LiangDepartment of Zoology, The University of British Columbia, Vancouver, Canada.
Berta VidalDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Emily A BayerDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Weidong FengDepartment of Neurobiology, University of Chicago, Chicago, United States.
Estanisla Daniel De La CruzDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Laura CrociDivision of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
G Giacomo ConsalezDivision of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
Kota MizumotoDepartment of Zoology, The University of British Columbia, Vancouver, Canada.
Oliver HobertDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID 0000-0002-7634-2854
Howard Hughes Medical Institute · USUniversity of Chicago · USSan Raffaele University of Rome · ITUniversity of British Columbia · CA

Funding

Sexually dimorphic regulation of neuronal identity in C.elegansR37NS039996 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HOBERT, OLIVER · 2015 to 2021
$2.5M
Gene regulatory mechanisms that assign and maintain motor neuron terminal differeR00NS084988 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS · 2016 to 2018
$739k
Howard Hughes Medical InstituteNINDS NIH HHS R00 NS084988NINDS NIH HHS R37 NS039996
6 · The paper itself

Abstract

A core principle of nervous system organization is the diversification of neuron classes into subclasses that share large sets of features but differ in select traits. We describe here a molecular mechanism necessary for motor neurons to acquire subclass-specific traits in the nematode

Indexed as

Cell DifferentiationGene Expression Regulation, DevelopmentalAnimalsBiological Variation, PopulationCaenorhabditis elegansCaenorhabditis elegans ProteinsHomeodomain ProteinsMiceMotor NeuronsTranscription FactorsCaenorhabditis elegans ProteinsHomeodomain ProteinsTranscription Factorsunc-3 protein, C elegansC. elegansneuronal differentiationneurosciencetranscriptional control

Identifiers

PMID28677525
PMCPMC5498135
OpenAlexW2732659948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.