Evidence map›Paper›PMID 28677267›Full record

ArticleHLA2017

Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing.

G M Venkataraman, L J Kennedy, M-T E Little, S S Graves, M A Harkey, B J Torok-Storb, R Storb

Open access · greenAbstract read
In one paragraph

Article in HLA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

G M VenkataramanClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
L J KennedyCentre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
M-T E LittleClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
S S GravesClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
M A HarkeyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-2621-1450
B J Torok-StorbClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
R StorbClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Fred Hutch Cancer Center · USUniversity of Washington · USUniversity of Manchester · GB

Funding

Project 3: Stem Cell Allografts for Lymphoid MalignanciesP01CA078902 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SANDMAIER, BRENDA MARIE · 1999 to 2025
$46.1M
CORE--VECTOR PRODUCTIONP30DK056465 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HEIMFELD, SHELLY · 1999 to 2014
$14.9M
Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1M
NCI NIH HHS P01 CA078902NIDDK NIH HHS P30 DK056465NIDDK NIH HHS U54 DK106829
6 · The paper itself

Abstract

Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.

Indexed as

AllelesPolymorphism, GeneticAnimalsDogsGenotyping TechniquesHistocompatibility Antigens Class IHistocompatibility Antigens Class Iallelecanineclass IDLA-88dogdog leukocyte antigenmajor histocompatibility complex

Identifiers

PMID28677267
PMCPMC5551428
OpenAlexW2730337357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.