ArticleHuman brain mapping2017
Brain changes following four weeks of unimanual motor training: Evidence from behavior, neural stimulation, cortical thickness, and functional MRI.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Cortical Thickness of Brain Areas Beyond Stroke Lesions and Sensory-Motor Recovery: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
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- Neurosciences and Sports Rehabilitation in ACLR: A Narrative Review on Winning Alliance Strategies and Connecting the Dots.Journal of functional morphology and kinesiology · 2025Review
- Relating cortical morphology, corticospinal excitability, corticomotor representation, and quadriceps strength after anterior cruciate ligament injury.Experimental brain research · 2025Article
- Regional gray matter thickness correlations of the hearing and deaf feline brains.Neuroimage. Reports · 2025Article
- Experience-driven competition in neural reorganization after stroke.The Journal of physiology · 2025Review
- Brain network of athletes in motor imagery and action anticipation: an ALE meta-analysis and MACM analysis.Frontiers in sports and active living · 2025Review
- Objective Neurophysiological Measures of Cognitive Performance in Elite Ice Hockey Players.Open access journal of sports medicine · 2025Article
- An fMRI study on the generalization of motor learning after brain actuated supernumerary robot training.NPJ science of learning · 2024Article
- Investigating female versus male differences in white matter neuroplasticity associated with complex visuo-motor learning.Scientific reports · 2024Article
- Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function.NeuroImage · 2024Article
- Sex differences in patterns of white matter neuroplasticity after balance training in young adults.Frontiers in human neuroscience · 2024Article
- Cortical circuit dynamics underlying motor skill learning: from rodents to humans.Frontiers in molecular neuroscience · 2023Review
- Active versus resting neuro-navigated robotic transcranial magnetic stimulation motor mapping.Physiological reports · 2022Article
- Sling Exercise Can Drive Cortical Representation of the Transversus Abdominis and Multifidus Muscles in Patients With Chronic Low Back Pain.Frontiers in neurology · 2022Article
- The Proactive Synergy Between Action Observation and Execution in the Acquisition of New Motor Skills.Frontiers in human neuroscience · 2022Article
- Imaging functional neuroplasticity in human white matter tracts.Brain structure & function · 2022Article
- Article
- Neuromuscular Electrical Stimulation Primes Feedback Control During a Novel Single Leg Task.Journal of motor behavior · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although different aspects of neuroplasticity can be quantified with behavioral probes, brain stimulation, and brain imaging assessments, no study to date has combined all these approaches into one comprehensive assessment of brain plasticity. Here, 24 healthy right-handed participants practiced a sequence of finger-thumb opposition movements for 10 min each day with their left hand. After 4 weeks, performance for the practiced sequence improved significantly (P < 0.05 FWE) relative to a matched control sequence, with both the left (mean increase: 53.0% practiced, 6.5% control) and right (21.0%; 15.8%) hands. Training also induced significant (cluster p-FWE < 0.001) reductions in functional MRI activation for execution of the trained sequence, relative to the control sequence. These changes were observed as clusters in the premotor and supplementary motor cortices (right hemisphere, 301 voxel cluster; left hemisphere 700 voxel cluster), and sensorimotor cortices and superior parietal lobules (right hemisphere 864 voxel cluster; left hemisphere, 1947 voxel cluster). Transcranial magnetic stimulation over the right ("trained") primary motor cortex yielded a 58.6% mean increase in a measure of motor evoked potential amplitude, as recorded at the left abductor pollicis brevis muscle. Cortical thickness analyses based on structural MRI suggested changes in the right precentral gyrus, right post central gyrus, right dorsolateral prefrontal cortex, and potentially the right supplementary motor area. Such findings are consistent with LTP-like neuroplastic changes in areas that were already responsible for finger sequence execution, rather than improved recruitment of previously nonutilized tissue. Hum Brain Mapp 38:4773-4787, 2017. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.