Evidence map›Paper›PMID 28677065›Full record

ArticleEuropean radiology2018

Ferumoxytol-enhanced magnetic resonance angiography for the assessment of potential kidney transplant recipients.

Sokratis Stoumpos, Martin Hennessy, Alex T Vesey, Aleksandra Radjenovic, Ram Kasthuri, David B Kingsmore, Patrick B Mark, Giles Roditi

Open access · hybridAbstract read
In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Guideline
  2. Review
  3. Review
  4. Article
  5. Article
  6. Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Nano-embedded medical devices and delivery systems in interventional radiology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Two Non-gadolinium-based, Innovative Approaches to Preoperative Lymphangiography.Plastic and reconstructive surgery. Global open · 2020
    Article
  17. Article
  18. Noncontrast MR angiography: An update.Journal of magnetic resonance imaging : JMRI · 2019
    Review
  19. A Case of Ferumoxytol (FerahemeJournal of clinical imaging science · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sokratis StoumposRenal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK. Sokratis.Stoumpos@glasgow.ac.uk.ORCID http://orcid.org/0000-0002-4138-5002
Martin HennessyDepartment of Radiology, Queen Elizabeth University Hospital, Glasgow, UK.
Alex T VeseyRenal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Aleksandra RadjenovicInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK.
Ram KasthuriDepartment of Radiology, Queen Elizabeth University Hospital, Glasgow, UK.
David B KingsmoreRenal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Patrick B MarkRenal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Giles RoditiDepartment of Radiology, Queen Elizabeth University Hospital, Glasgow, UK.
Queen Elizabeth University Hospital · GBUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTraditional contrast-enhanced methods for scanning blood vessels using magnetic resonance imaging (MRI) or CT carry potential risks for patients with advanced kidney disease. Ferumoxytol is a superparamagnetic iron oxide nanoparticle preparation that has potential as an MRI contrast agent in assessing the vasculature.

methodsTwenty patients with advanced kidney disease requiring aorto-iliac vascular imaging as part of pre-operative kidney transplant candidacy assessment underwent ferumoxytol-enhanced magnetic resonance angiography (FeMRA) between December 2015 and August 2016. All scans were performed for clinical indications where standard imaging techniques were deemed potentially harmful or inconclusive. Image quality was evaluated for both arterial and venous compartments.

resultsFirst-pass and steady-state FeMRA using incremental doses of up to 4 mg/kg body weight of ferumoxytol as intravenous contrast agent for vascular enhancement was performed. Good arterial and venous enhancements were achieved, and FeMRA was not limited by calcification in assessing the arterial lumen. The scans were diagnostic and all patients completed their studies without adverse events.

conclusionsOur preliminary experience supports the feasibility and utility of FeMRA for vascular imaging in patients with advanced kidney disease due for transplant listing, which has the advantages of obtaining both arteriography and venography using a single test without nephrotoxicity. KEY POINTS: • Evaluation of vascular disease is important in planning kidney transplantation. • Standard vascular imaging methods are often problematic in kidney disease patients. • FeMRA has the advantage of arteriography and venography in a single test. • FeMRA is safe and non-nephrotoxic. • FeMRA is not limited by arterial calcification.

Indexed as

Contrast MediaFerrosoferric OxideKidney TransplantationPatient SelectionFemaleHumansImage EnhancementKidneyMagnetic Resonance AngiographyMaleMiddle AgedContrast MediaFerrosoferric OxideAngiographyFerric compoundsKidney failure, chronicKidney transplantationMagnetic resonance imaging

Identifiers

PMID28677065
PMCPMC5717122
OpenAlexW2729798514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.