ReviewCurrent treatment options in cardiovascular medicine2017
Symptomatic Carotid Artery Stenosis: Surgery, Stenting, or Medical Therapy?
Review in Current treatment options in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- The Role of Large Artery Atherosclerosis and Predictive Risk Factors in Symptomatic and Asymptomatic Ischemic Stroke.Noro psikiyatri arsivi · 2026Article
- Evaluation of ocular blood flow in the assessment of symptomatic carotid stenosis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Ocular Structural and Vascular Changes in Patients with Severe Asymptomatic Carotid Disease After Undergoing Carotid Endarterectomy (CEA) and Carotid Artery Stenting (CAS).Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Non-traditional lipid parameters are independent predictors of the location, distribution, and stroke events of moderate-to-severe intracranial and extracranial atherosclerotic stenosis.Frontiers in neurology · 2025Article
- Intravascular lithotripsy followed by angioplasty and stenting for severely calcified carotid artery stenosis: technical note and case series.Frontiers in neurology · 2025Article
- Peri-Carotid Adipose Tissue and Atherosclerosis at Carotid Bifurcation.Journal of cardiovascular development and disease · 2024Article
- Risk factors of in-stent restenosis after carotid angioplasty and stenting: long-term follow-up study.Frontiers in neurology · 2024Article
- Carotid Artery Stenosis: A Look Into the Diagnostic and Management Strategies, and Related Complications.Cureus · 2023Review
- Characteristics of the gut microbiota of patients with symptomatic carotid atherosclerotic plaques positive for bacterial genetic material.Frontiers in cellular and infection microbiology · 2023Article
- B-mode ultrasound characteristics of carotid plaques in symptomatic and asymptomatic patients with low-grade stenosis.PloS one · 2023Article
- Fluid structure interaction versus rigid-wall approach in the study of the symptomatic stenosed carotid artery: Importance of wall compliance and resilience of loose connective tissue.International journal for numerical methods in biomedical engineering · 2022Article
- CYP2C19 Loss-of-Function Associated with First-Time Ischemic Stroke in Non-surgical Asymptomatic Carotid Artery Stenosis During Clopidogrel Therapy.Translational stroke research · 2022Article
- Review
- Evaluation of ischemic lesions after carotid artery stenting with diffusion-weighted imaging.World journal of clinical cases · 2020Article
- Non-Contrast-Enhanced Carotid MRA: Clinical Evaluation of a Novel Ungated Radial Quiescent-Interval Slice-Selective MRA at 1.5T.AJNR. American journal of neuroradiology · 2019Article
- Clinical risk factors predictive of thrombotic stroke with large cerebral infarction.Neurology international · 2019Article
- Significant changes of the choroid in patients with ocular ischemic syndrome and symptomatic carotid artery stenosis.PloS one · 2019Article
- Extracranial Artery Stenosis Is Associated With Total MRI Burden of Cerebral Small Vessel Disease in Ischemic Stroke Patients of Suspected Small or Large Artery Origins.Frontiers in neurology · 2019Article
- Biomarker Profiling of Neurovascular Diseases in Patients with Stage 5 Chronic Kidney Disease.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
opinion statementSymptomatic carotid artery disease is a significant cause of ischemic stroke, and these patients are at high risk for recurrent vascular events. Patients with symptoms of stroke or transient ischemic attack attributable to a significantly stenotic vessel (70-99% luminal narrowing) should be treated with intensive medical therapy. Intensive medical therapy is a combination of pharmacologic and lifestyle interventions consistent with best-known practices as follows: initiation of antiplatelet agent or anticoagulation if medically indicated, high potency statin medication, blood pressure control with goal blood pressure of greater than 140/90, Mediterranean-style diet, exercise, and smoking cessation. Further, patients who have extracranial culprit lesions should be considered for revascularization with either carotid endarterectomy or carotid angioplasty and stenting depending on several factors including the patient's anatomy, age, gender, and procedural risk. Based on current evidence, patients with symptomatic intracranial stenosis should be managed with intensive medical therapy, including the use of dual antiplatelet therapy with aspirin and clopidogrel for the first 90 days following the ischemic event. While the literature has shown a stronger benefit of revascularization of extracranial symptomatic disease among certain subgroups of patients with greater than 70% stenosis, there is less benefit from revascularization with endarterectomy in patients with moderate stenosis of 50-69% if the surgeon's risk of perioperative stroke or death rate is greater than 6%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.