Evidence map›Paper›PMID 28677009›Full record

ArticleBreast cancer research and treatment2017

The effects of physical activity and fatigue on cognitive performance in breast cancer survivors.

Diane K Ehlers, Susan Aguiñaga, Josh Cosman, Joan Severson, Arthur F Kramer, Edward McAuley

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06953648 (Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06953648 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation (REMM-HIIT-HCT)

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2025 to 2030Enrolled126ConditionsHematopoietic Stem Cell Transplantation, Cardiorespiratory FitnessArmsHigh Intensity Interval Training
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  4. Effects of Baduanjin exercise on cognitive function and cancer-related symptoms in women with breast cancer receiving chemotherapy: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Diane K EhlersDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA. dkehlers@illinois.edu.
Susan AguiñagaDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Josh CosmanPfizer Incorporated, Cambridge, MA, USA.
Joan SeversonDigital Artefacts, Iowa City, IA, USA.
Arthur F KramerOffice of the Provost, Northeastern University, Boston, MA, USA.
Edward McAuleyDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
University of Illinois Urbana-Champaign · USDigital Artefacts (United States) · USNortheastern University · US

Funding

American Cancer Society PF-16-021-01-CPPBNCI NIH HHS L30 CA209645
6 · The paper itself

Abstract

purposeResearch suggests that physical activity may be a promising treatment for cancer-related cognitive impairment; however, evidence is limited by small samples and self-report measures and little is known about the underlying mechanisms. The purpose of this study was to examine the effects of physical activity on cognitive function in a national sample of breast cancer survivors (BCSs) using objective measures. We hypothesized that physical activity's effects on cognition would be indirect through survivors' self-reported fatigue.

methodsParticipants (N = 299; M = 57.51 ± 9.54 years) included BCSs with access to an iPad. Participants wore an accelerometer for seven consecutive days to measure their average daily minutes of moderate-to-vigorous physical activity (MVPA) and completed a battery of questionnaires and neuropsychological tests via an iPad application to measure fatigue and cognitive function. Cognitive function was modeled as two latent factors-executive function and working memory-comprising performance across seven cognitive tasks. A structural equation modeling framework was used to test the hypotheses.

resultsMVPA was associated with less fatigue (γ = 0.19), which, in turn, was associated with faster times on executive function tasks (γ = -0.18) and greater accuracy on working memory tasks (γ = 0.16). The indirect paths from MVPA to cognitive performance were also significant (executive function: β = -0.03, memory: β = 0.03).

conclusionsFindings suggest that MVPA may be associated with greater executive function and working memory in BCSs. Further, this effect may be partially indirect through cancer-related symptoms (e.g., fatigue). Results emphasize the need for additional scientific investigation in the context of prospective and efficacy trials.

Indexed as

Cancer SurvivorsCognitionExerciseFatigueAgedBreast NeoplasmsFemaleHumansMaze LearningMemoryMiddle AgedModels, TheoreticalSurveys and QuestionnairesBreast cancerCancer-related cognitive impairmentFatiguePhysical activity

Identifiers

PMID28677009
PMCPMC12257920
OpenAlexW2731963041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.