ReviewMammalian genome : official journal of the International Mammalian Genome Society2017
Modeling human disease in rodents by CRISPR/Cas9 genome editing.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Effect of a truncated mutant factor V on hemostatic function and embryonic development in mice.Scientific reports · 2026Article
- A Human HomozygousGenes · 2024Article
- CRISMERE Chromosome Engineering in Mouse and Rat.Methods in molecular biology (Clifton, N.J.) · 2023Article
- CRISPR/Cas9 system: a reliable and facile genome editing tool in modern biology.Molecular biology reports · 2022Review
- Rs1hGene therapy · 2022Article
- Article
- Advances in mouse genetics for the study of human disease.Human molecular genetics · 2021Review
- Sensory Innervation of the Larynx and the Search for Mucosal Mechanoreceptors.Journal of speech, language, and hearing research : JSLHR · 2021Article
- CRISPR-Cas9: A Preclinical and Clinical Perspective for the Treatment of Human Diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Review
- Ikaros-Associated Diseases: From Mice to Humans and Back Again.Frontiers in pediatrics · 2021Review
- CRISPR: a journey of gene-editing based medicine.Genes & genomics · 2020Review
- Cyclin-dependent kinases and rare developmental disorders.Orphanet journal of rare diseases · 2020Review
- Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa.EBioMedicine · 2020Article
- Generation of novel Il2rg-knockout mice with clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9.Experimental animals · 2020Article
- The abiding relevance of mouse models of rare mutations to psychiatric neuroscience and therapeutics.Schizophrenia research · 2020Article
- PATHBIO: an international training program for precision mouse phenotyping.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Disease modeling and stem cell immunoengineering in regenerative medicine using CRISPR/Cas9 systems.Computational and structural biotechnology journal · 2020Review
- Genetics and functions of the retinoic acid pathway, with special emphasis on the eye.Human genomics · 2019Review
- Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Review
- CRISPR links to long noncoding RNA function in mice: A practical approach.Vascular pharmacology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.