ArticleFish physiology and biochemistry2017
Comparative transcriptome analysis of molecular mechanism underlying gray-to-red body color formation in red crucian carp (Carassius auratus, red var.).
Article in Fish physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 81 citations in OpenAlex.
- Comprehensive circRNA Profiling Reveals a Testis-Specific circRNA circdmrt1 as a Novel Regulator of Gonadal Development in Crucian Carp.International journal of molecular sciences · 2026Article
- Melanin Deficiency Is Associated with Immune Homeostasis in the Critically Endangered Yangtze Sturgeon (International journal of molecular sciences · 2026Article
- Identification of Body Color-Related QTLs in Leopard Coral Grouper (Animals : an open access journal from MDPI · 2026Article
- Circular RNA profiling uncovers regulators of early body color transition in juvenile leopard coral grouper (Plectropomus leopardus).BMC genomics · 2026Article
- Identification of a Major QTL Associated with Body Color on ChrLG3 in Tilapia by GWAS.Marine biotechnology (New York, N.Y.) · 2025Article
- Functions of thyroid hormone signaling in regulating melanophore, iridophore, erythrophore, and pigment pattern formation in spotted scat (Scatophagus argus).BMC genomics · 2025Article
- Identification and effective regulation ofZoological research · 2024Article
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- Comparative Transcriptome Analysis of the Response toBiology · 2023Article
- Pigment Identification and Gene Expression Analysis during Erythrophore Development in Spotted Scat (International journal of molecular sciences · 2023Article
- Comparative transcriptome and miRNA analysis of skin pigmentation during embryonic development of Chinese soft-shelled turtle (Pelodiscus sinensis).BMC genomics · 2022Article
- MiR-382 Functions on the Regulation of Melanogenesis via Targeting dct in Rainbow Trout (Oncorhynchus mykiss).Marine biotechnology (New York, N.Y.) · 2022Article
- Transcriptome analysis of skin color variation during and after overwintering of Malaysian red tilapia.Fish physiology and biochemistry · 2022Article
- Analysis of yellow mutant rainbow trout transcriptomes at different developmental stages reveals dynamic regulation of skin pigmentation genes.Scientific reports · 2022Article
- Pterin-based pigmentation in animals.Biology letters · 2021Article
- Global tissue transcriptomic analysis to improve genome annotation and unravel skin pigmentation in goldfish.Scientific reports · 2021Article
- Identification of Potential Blind-Side Hypermelanosis-Related lncRNA-miRNA-mRNA Regulatory Network in a Flatfish Species, Chinese Tongue Sole (Frontiers in genetics · 2021Article
- QTL Mapping for Red Blotches in Malaysia Red Tilapia (Oreochromis spp.).Marine biotechnology (New York, N.Y.) · 2019Article
- Morphological Characteristics and Comparative Transcriptome Analysis of Three Different Phenotypes ofFrontiers in genetics · 2019Article
- Comparative Transcriptome and DNA methylation analyses of the molecular mechanisms underlying skin color variations in Crucian carp (Carassius carassius L.).BMC genetics · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Red crucian carp (Carassius auratus red var.) is an ornamental fish with vivid red/orange color. It has been found that the adult body color of this strain forms a gray-to-red change. In this study, skin transcriptomes of red crucian carp are first obtained for three different stages of body color development, named by gray-color (GC), color-variation (CV), and red-color (RC) stages, respectively. From the skins of GC, CV, and RC, 103,229; 108,208; and 120,184 transcripts have been identified, respectively. Bioinformatics analysis reveals that 2483, 2967, and 4473 unigenes are differentially expressed between CV and GC, RC and CV, and RC and GC, respectively. A part of the differentially expressed genes (DEGs) are involved in the signaling pathway of pigment synthesis, such as the melanogenesis genes (Mitfa, Pax3a, Foxd3, Mc1r, Asip); tyrosine metabolism genes (Tyr, Dct, Tyrp1, Silva, Tat, Hpda); and pteridine metabolism genes (Gch, Xdh, Ptps, Tc). According to the data of transcriptome and quantitative PCR, the expression of Mitfa and its regulated genes which include the genes of Tyr, Tyrp1, Dct, Tfe3a, and Baxα, decreases with gray-to-red change. It is suggested that Mitfa and some genes, being related to melanin synthesis or melanophore development, are closely related to the gray-to-red body color transformation in the red crucian carp. Furthermore, the DEGs of cell apoptosis and autophagy pathway, such as Tfe3a, Baxα, Hsp70, Beclin1, Lc3, Atg9a, and Atg4a, might be involved in the melanocytes fade away of juvenile fish. These results shed light on the regulation mechanism of gray-to-red body color transformation in red crucian carp, and are helpful to the selective breeding of ornamental fish strains.
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