Evidence map›Paper›PMID 28676917›Full record

ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2017

Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential.

Daniele Tibullo, Giovanni Li Volti, Cesarina Giallongo, Sonia Grasso, Daniele Tomassoni, Carmelina Daniela Anfuso, Gabriella Lupo, Francesco Amenta, Roberto Avola, Vincenzo Bramanti

Registry-linked trialOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05808946 (The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis), which is not on this map. Cited by 113 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 2 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05808946 phase2 / phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis

TypeinterventionalSponsorAin Shams UniversityRan2023 to 2024Enrolled60ConditionsSepsisArmsAlpha-Lipoic Acid, Sepsis Supportive Care
3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 2 syntheses or guidelines pooled it, 239 citations in OpenAlex.

  1. Role of lipoic acid in multiple sclerosis.CNS neuroscience & therapeutics · 2022
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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Daniele TibulloSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy.
Giovanni Li VoltiSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy.
Cesarina GiallongoSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy.
Sonia GrassoSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy.
Daniele TomassoniSchool of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy.
Carmelina Daniela AnfusoSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy.
Gabriella LupoSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy.
Francesco AmentaSchool of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy.
Roberto AvolaSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy. ravola@unict.it.
Vincenzo BramantiSection of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 89, 95123, Catania, Italy.
University of Catania · ITUniversità di Camerino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe molecular nature of lipoic acid (LA) clarifies its capability of taking part to a variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is the antioxidant activity due to its ability to scavenge and inactivate free radicals. Furthermore, LA has been shown to chelate toxic metals both directly and indirectly by its capability to enhance intracellular glutathione (GSH) levels. This last property is due to its ability to interact with GSH and recycle endogenous GSH. LA exhibits significant antioxidant activity protecting against oxidative damage in several diseases, including neurodegenerative disorders. Interestingly, LA is unique among natural antioxidants for its capability to satisfy a lot of requirements, making it a potentially highly effective therapeutic agent for many conditions related with oxidative damage. In particular, there are evidences showing that LA has therapeutic activity in lowering glucose levels in diabetic conditions. Similarly, LA supplementation has multiple beneficial effects on the regression of the mitochondrial function and on oxidative stress associated with several diseases and aging.

aimThe aim of the present review is to describe the molecular mechanisms underlying the beneficial effects of LA under various experimental conditions and disease and how to exploit such effect for clinical purposes.

conclusionLA has pleiotropic effects in different pathways related with several diseases, its use as a potential therapeutic agent is very promising.

Indexed as

Anti-Inflammatory AgentsAntioxidantsThioctic AcidAnimalsHumansSignal TransductionAnti-Inflammatory AgentsAntioxidantsThioctic AcidAlpha lipoic acidAntioxidantChelationFree radical scavengerGlutathioneInflammationTherapeutic potential

Identifiers

PMID28676917
OpenAlexW2731618083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.