ArticleJournal of assisted reproduction and genetics2017
Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos.
Article in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate?Journal of assisted reproduction and genetics · 2023Pooled it
- Trial
- First cleavage signatures define a temporal trade-off and predict embryo fitness.Scientific reports · 2026Article
- Non-invasive assessment of embryo development and ploidy: morphokinetics predict blastulation, and exploratory metabolomics identifies candidate metabolic signatures for euploidy.Frontiers in cell and developmental biology · 2026Article
- Prediction of human embryo ploidy based on morphokinetic parameters: Investigating the use of time-lapse imaging for non-invasive embryo selection.JBRA assisted reproduction · 2025Article
- Correlation between Human Embryo Morphokinetics Observed through Time-Lapse Incubator and Life Birth Rate.Journal of personalized medicine · 2024Article
- Morphokinetic Profiling Suggests That Rapid First Cleavage Division Accurately Predicts the Chances of Blastulation in Pig In Vitro Produced Embryos.Animals : an open access journal from MDPI · 2024Article
- The morphokinetic signature of human blastocysts with mosaicism and the clinical outcomes following transfer of embryos with low-level mosaicism.Journal of ovarian research · 2024Article
- Steady morphokinetic progression is an independent predictor of live birth: a descriptive reference for euploid embryos.Human reproduction open · 2024Article
- Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status.Journal of assisted reproduction and genetics · 2023Article
- The use of voting ensembles to improve the accuracy of deep neural networks as a non-invasive method to predict embryo ploidy status.Journal of assisted reproduction and genetics · 2023Article
- Incidence, dynamics and recurrences of reverse cleavage in aneuploid, mosaic and euploid blastocysts, and its relationship with embryo quality.Journal of ovarian research · 2022Article
- Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.JBRA assisted reproduction · 2022Review
- Change in the Strategy of Embryo Selection with Time-Lapse System Implementation-Impact on Clinical Pregnancy Rates.Journal of clinical medicine · 2021Article
- What is the clinical impact of the endometrial receptivity array in PGT-A and oocyte donation cycles?Journal of assisted reproduction and genetics · 2019Article
- Impact of polar body biopsy on embryo morphokinetics-back to the roots in preimplantation genetic testing?Journal of assisted reproduction and genetics · 2018Article
- The clinical use of time-lapse in human-assisted reproduction.Therapeutic advances in reproductive healthReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThis study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status.
methodsPatients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subjected to trophectoderm biopsy and microarray comparative genomic hybridization (array-CGH). Blastocyst development process was analyzed using time-lapse images.
resultsMorphokinetic parameters: tPNf, t2, t3, t4, t5, t8, t9, tcom, tM, tSB, tB, tEB, CC1, CC2, CC3, S2, S3, t5-t2, and tB-tSB showed no significant difference in euploid embryos compared to aneuploid counterparts. In addition, two risk models based on previously published morphokinetic parameters failed to segregate euploid from aneuploid embryos.
conclusionsMorphokinetic parameters subjected to investigation in the present study failed to improve the chance of selecting euploid embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.