ArticleFrontiers in human neuroscience2017
Preliminary Evidence for Training-Induced Changes of Morphology and Phantom Limb Pain.
Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Targeted Muscle Reinnervation-an Up-to-Date Review: Evidence, Indications, and Technique.Archives of plastic surgery · 2025Article
- Treatment of Phantom and Residual Limb Pain in Amputees With Targeted Muscle Reinnervation.Eplasty · 2025Article
- [Clinical updates on phantom limb pain : German version].Schmerz (Berlin, Germany) · 2023Review
- Detangling the Structural Neural Correlates Associated with Resting versus Dynamic Phantom Limb Pain Intensity Using a Voxel-based Morphometry Analysis.Pain medicine (Malden, Mass.) · 2023Article
- Current status and clinical perspectives of extended reality for myoelectric prostheses: review.Frontiers in bioengineering and biotechnology · 2023Review
- Experience of adults with upper-limb difference and their views on sensory feedback for prostheses: a mixed methods study.Journal of neuroengineering and rehabilitation · 2022Article
- Morphometric similarity networks discriminate patients with lumbar disc herniation from healthy controls and predict pain intensity.Frontiers in network physiology · 2022Article
- The Need to Work Arm in Arm: Calling for Collaboration in Delivering Neuroprosthetic Limb Replacements.Frontiers in neurorobotics · 2021Review
- Structural and functional motor cortex asymmetry in unilateral lower limb amputation with phantom limb pain.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Commentary: Preliminary Evidence for Training-Induced Changes of Morphology and Phantom Limb Pain.Frontiers in human neuroscience · 2019Article
- The Stochastic Entanglement and Phantom Motor Execution Hypotheses: A Theoretical Framework for the Origin and Treatment of Phantom Limb Pain.Frontiers in neurology · 2018Article
- Leg Prosthesis With Somatosensory Feedback Reduces Phantom Limb Pain and Increases Functionality.Frontiers in neurology · 2018Article
- Clinical updates on phantom limb pain.Pain reportsArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate whether a special prosthetic training in phantom limb pain patients aimed at increasing the functional use of the prosthesis leads to neural morphological plasticity of brain structures and a reduction in phantom limb pain. For chronic pain disorders, it was shown that morphological alterations due to pain might become at least partially reversed by pain therapies. Phantom limb pain is a chronic pain disorder that is frequently followed by neural plasticity of anatomical brain structures. In our study, 10 patients with amputation of the upper limb participated in a two-week training with a myoelectric prosthesis with somatosensory feedback. Grip strength was fed back with electrocutaneous stimulus patterns applied to the stump. Phantom limb pain was assessed before and after the two-week training. Similarly, two T1 weighted MRI scans were conducted for longitudinal thickness analyses of cortical brain structures. As result of this treatment, patients experienced a reduction in phantom limb pain and a gain in prosthesis functionality. Furthermore, we found a change of cortical thickness in small brain areas in the visual stream and the post-central gyrus ipsilateral to the amputation indicating morphological alterations in brain areas involved in vision and pain processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.