Evidence map›Paper›PMID 28676695›Full record

ArticleScientific reports2017

Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations.

Liuyan Zeng, Shengqun Luo, Xin Li, Mengxuan Lu, Huahui Li, Tong Li, Guanhua Wang, Xiaoming Lyu, Wenrui Jia, Zigang Dong and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Expression and significance of pin1 in the wound healing.Archives of dermatological research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Liuyan ZengDepartment of health management center, the affiliated hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Shengqun LuoChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Xin LiCancer Research Institute, Southern Medical University, Guangzhou, 510515, China.
Mengxuan LuChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Huahui LiChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Tong LiChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Guanhua WangChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Xiaoming LyuDepartment of laboratory medicine, the third affiliated hospital of Southern Medical University, Guangzhou, China.
Wenrui JiaSchool of Laboratory Medicine, Guangdong Medical University, Dongguan, China.
Zigang DongThe Hormel Institute, University of Minnesota, 801, 16th AVE, NE, Austin, MN, 55912, USA.
Qiang JiangCancer Research Institute, Southern Medical University, Guangzhou, 510515, China.
Zhihua ShenChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Guo-Liang HuangChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China. huanguoliang@gdmu.edu.cn.
Zhiwei HeChina-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China; Key Laboratory for Epigenetics of Dongguan City; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China. zhiweihe688@yahoo.com.
Key Laboratory of Guangdong Province · CNGuangdong Medical College · CNSouthern Medical University · CNThird Affiliated Hospital of Southern Medical University · CNUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous work reported the association between two single nucleotide polymorphisms (SNPs) in PIN1 promoter and nasopharyngeal carcinoma (NPC) risk with a small sample size in a low incidence area. This study investigated the association between the two SNPs and NPC risk in 733 patients and 895 controls from a high incidence area. The results indicated the genotype and allele frequencies of -842G > C and -667C > T were both significantly different between patients and controls even using the resampling statistics. The -842GC and -667TT genotypes showed a significantly increased risk of NPC (OR = 1.977, 95% CI = 1.339-2.919, P = 0.001 and OR = 1.438, 95% CI = 1.061-1.922, P = 0.019, respectively). Compared to the most common -842G-667C haplotype, -842G-667T haplotype and -842C-667C haplotype showed a significantly increased risk of NPC (OR = 1.215, 95% CI = 1.053-1.402, P = 0.008 and OR = 2.268, 95% CI = 1.530-3.362, P = 0.001, respectively). Further reporter gene expression suggested that variant -842C-667C and -842G-667T were associated with an enhanced transcriptional activity. In conclusion, our findings suggest that -842G > C and -667C > T in PIN1 promoter are associated with NPC risk; as well as the promoter activity is mediated by functional PIN1 variants.

Indexed as

Polymorphism, Single NucleotideAdultAgedAsian PeopleCase-Control StudiesCell Line, TumorFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNIMA-Interacting Peptidylprolyl IsomerasePromoter Regions, GeneticNIMA-Interacting Peptidylprolyl IsomerasePIN1 protein, human

Identifiers

PMID28676695
PMCPMC5496913
OpenAlexW2731847768

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.