ArticleScientific reports2017
Transcriptomic profiling of Melilotus albus near-isogenic lines contrasting for coumarin content.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Sweet Clover (Molecules (Basel, Switzerland) · 2025Article
- A comparative plastome approach enhances the assessment of genetic variation in the Melilotus genus.BMC genomics · 2024Article
- Analysis of the difference between early-bolting and non-bolting roots of Angelica dahurica based on transcriptome sequencing.Scientific reports · 2023Article
- Review
- Effects of Light Intensity on Physiological Characteristics and Expression of Genes in Coumarin Biosynthetic Pathway ofInternational journal of molecular sciences · 2022Article
- Improved plant heat shock resistance is introduced differently by heat and insect infestation: the role of volatile emission traits.Oecologia · 2022Article
- Genome and systems biology of Melilotus albus provides insights into coumarins biosynthesis.Plant biotechnology journal · 2022Article
- Transcriptomic profiling suggests candidate molecular responses to waterlogging in cassava.PloS one · 2022Article
- Genome-Wide Analysis of the UDP-Glycosyltransferase Family Reveals Its Roles in Coumarin Biosynthesis and Abiotic Stress inInternational journal of molecular sciences · 2021Article
- NAC and MYB Families and Lignin Biosynthesis-Related Members Identification and Expression Analysis inPlants (Basel, Switzerland) · 2021Article
- De novo transcriptome analysis ofPeerJ · 2020Article
- The complete chloroplast genome ofMitochondrial DNA. Part B, Resources · 2018Article
- Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
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9 authors at 1 institution in 1 country.
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Abstract
Coumarin and its derivatives are widely used as fragrances in industrial products and have medical value. The goal of the present study was to discover genes and pathways related to coumarin biosynthesis in Melilotus albus using transcriptome analysis. The genes of five M. albus near-isogenic lines (NILs) that had different coumarin content and β-glucosidase activity according to the investigation of pedigree were quantified and then analysed by RNA-Seq. Using transcriptome analysis, differentially expressed genes (DEGs) were identified in two pairwise comparisons that differed in coumarin content as well as in two pairwise comparisons that differed in β-glucosidase activity. Gene expression pattern analysis suggested similar transcriptional trends in the genotypes with the same coumarin levels. Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) database of DEGs was used to identify functional pathways associated with coumarin biosynthesis. We identified 111 unigenes, with several DEGs among them possibly being related to coumarin synthesis pathways. Unigenes encoding a hexokinase, an abscisic acid receptor, a phenylalanine ammonia-lyase (PAL) and two peroxidases particularly showed correspondence with the coumarin content of different genotypes. These results will contribute to a better understanding of the coumarin biosynthesis in M. albus.
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