Evidence map›Paper›PMID 28676574›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Aberrant Sodium Channel Currents and Hyperexcitability of Medial Entorhinal Cortex Neurons in a Mouse Model of

Matteo Ottolini, Bryan S Barker, Ronald P Gaykema, Miriam H Meisler, Manoj K Patel

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

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  15. Review
  16. Somatostatin-Positive Interneurons Contribute to Seizures inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Resurgent Sodium Current in Neurons of the Cerebral Cortex.Frontiers in cellular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Matteo OttoliniDepartment of Anesthesiology and.
Bryan S BarkerDepartment of Anesthesiology and.ORCID 0000-0001-6808-4472
Ronald P GaykemaDepartment of Anesthesiology and.ORCID 0000-0002-4166-700X
Miriam H MeislerDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109.
Manoj K PatelDepartment of Anesthesiology and mkp5u@virginia.edu.ORCID 0000-0003-3591-6716
University of Virginia Health System · USUniversity of Michigan · US

Funding

The neuronal sodium channel gene SCN8AR01NS034509 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MIRIAM H MEISLER · 1996 to 2026
$9.5M
Sodium channels and neuronal excitability in chronic limbic epilepsy.R01NS075157 · NINDS · UNIVERSITY OF VIRGINIA · PI PATEL, MANOJ K · 2012 to 2016
$1.7M
NINDS NIH HHS R01 NS034509NINDS NIH HHS R01 NS075157
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Disease Models, AnimalAction PotentialsAnimalsBrain DiseasesBrugada SyndromeEntorhinal CortexEpilepsyFemaleGene Knock-In TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMutationNAV1.6 Voltage-Gated Sodium ChannelNeuronsNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseSodium Channelsaction potentialentorhinal cortexepilepsyepileptic encephalopathySCN8Asodium channels

Identifiers

PMID28676574
PMCPMC5551062
OpenAlexW2724377668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.