Evidence map›Paper›PMID 28676241›Full record

ArticleNeuroscience2018

Age-Dependent Sexual Dimorphism in Susceptibility to Develop Chronic Pain in the Rat.

Luiz F Ferrari, Dioneia Araldi, Paul Green, Jon D Levine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Neuroinflammation and Pediatric Chronic Pain - A Review.Current pain and headache reports · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luiz F FerrariDepartments of Medicine and Oral Surgery, and Division of Neuroscience, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: Luiz.Ferrari@ucsf.edu.
Dioneia AraldiDepartments of Medicine and Oral Surgery, and Division of Neuroscience, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: Dioneia.Araldi@ucsf.edu.
Paul GreenDepartments of Oral & Maxillofacial Surgery, Preventive & Restorative Dental Sciences, and Division of Neuroscience, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: Paul.Green@ucsf.edu.
Jon D LevineDepartments of Medicine and Oral Surgery, and Division of Neuroscience, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: jon.levine@ucsf.edu.
University of California, San Francisco · US

Funding

Nociceptor mechanisms in the transition from acute to chronic painR01NS084545 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2014 to 2018
$3.1M
NINDS NIH HHS R01 NS084545
6 · The paper itself

Abstract

Neonatal pain has been suggested to contribute to the development and/or persistence of adult pain. Observations from animal models have shown that neonatal inflammation produces long-term changes in sensory neuron function, which can affect the susceptibility of adults to develop persistent pain. We used a preclinical model of transition to chronic pain, hyperalgesic priming, in which a previous inflammatory stimulus triggers a long-lasting increase in responsiveness to pro-algesic mediators, prototypically prostaglandin E

Indexed as

Sex CharacteristicsAgingAnimalsChronic PainDinoprostoneFemaleFulvestrantHyperalgesiaMaleRatsRepetition PrimingTumor Necrosis Factor-alphaDinoprostoneFulvestrantTumor Necrosis Factor-alphachronic painestrogenhyperalgesiahyperalgesic primingnociceptorrat

Identifiers

PMID28676241
PMCPMC5748377
OpenAlexW2729687317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.