ArticleStem cell research & therapy2017
Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo.
Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury.Cellular and molecular life sciences : CMLS · 2024Review
- Transplantation of Skeletal Muscle-Derived Sca-1Cells · 2022Article
- Transplantation to study satellite cell heterogeneity in skeletal muscle.Frontiers in cell and developmental biology · 2022Review
- Optimization of human myoblasts culture under different media conditions for application in theAmerican journal of stem cells · 2022Article
- Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor.Stem cell research & therapy · 2021Article
- Technical requirements for cultured meat production: a review.Journal of animal science and technology · 2021Review
- Increased Exhaustion of the Subchondral Bone-Derived Mesenchymal Stem/ Stromal Cells in Primary Versus Dysplastic Osteoarthritis.Stem cell reviews and reports · 2020Article
- Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration.Stem cell research & therapy · 2020Article
- Marker Expression of Interstitial Cells in Human Skeletal Muscle: An Immunohistochemical Study.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Adult stem cells at work: regenerating skeletal muscle.Cellular and molecular life sciences : CMLS · 2019Review
- The role of satellite and other functional cell types in muscle repair and regeneration.Journal of muscle research and cell motility · 2019Review
- A modified preplate technique for efficient isolation and proliferation of mice muscle-derived stem cells.Cytotechnology · 2018Article
- Muscle Stem/Progenitor Cells and Mesenchymal Stem Cells of Bone Marrow Origin for Skeletal Muscle Regeneration in Muscular Dystrophies.Archivum immunologiae et therapiae experimentalis · 2018Review
- Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration?Stem cell reviews and reports · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration and growth capability ex vivo. This study investigated the potential of muscle-derived PW1
methodsSca-1
resultsIsolated PICs expressed markers of pluripotency (Oct3/4, Sox2, and Nanog), were clonogenic, and self-renewing with >60 population doublings, and a population doubling time of 15.8 ± 2.9 h. PICs demonstrated an ability to generate both striated and smooth muscle, whilst also displaying the potential to differentiate into cell types of the three germ layers both in vitro and in vivo. Moreover, PICs did not form tumours in vivo.
conclusionThese findings open new avenues for a variety of solid tissue engineering and regeneration approaches, utilising a single multipotent stem cell type isolated from an easily accessible source such as skeletal muscle.
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Registered trials
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