ArticleBMC microbiology2017
The effects of probiotic Bacillus subtilis on the cytotoxicity of Clostridium perfringens type a in Caco-2 cell culture.
Article in BMC microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Probiotic properties ofFrontiers in microbiology · 2026Article
- Staphylococcus epidermidis MB614 and Staphylococcus hominis MB621 from human milk as up regulators of TNF-α induced IL-8 production by Caco-2 cell line.BMC biotechnology · 2025Article
- Toxicity study of SARS-CoV-2 Spike protein expressed on Bacillus subtilis spores.BMC microbiology · 2025Article
- Cytotoxic effects of epsilon toxin fromToxicology research · 2025Article
- Investigating the production and synergistic antibacterial activity of bacteriocin-like substance fromHeliyon · 2025Article
- Winning the battle of intestinal peace withFrontiers in microbiology · 2025Review
- Anti-inflammatory, antioxidant effects, and antimicrobial effect ofFood science and biotechnology · 2024Article
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- Simple neutralization test report: Do probiotics contribute to COVID-19 therapy?Biochemistry and biophysics reports · 2022Article
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- Expression of α- and ε-toxin genes inIranian journal of veterinary research · 2022Article
- Probiotic effect ofJournal of advanced veterinary and animal research · 2021Article
- Interaction between the probioticIranian journal of microbiology · 2021Article
- Oxalate-Degrading Bacillus subtilis Mitigates Urolithiasis in a Drosophila melanogaster Model.mSphere · 2020Article
- Oxygen-Limiting Growth Conditions and Deletion of the Transition State Regulator Protein Abrb in Bacillus subtilis 6633 Result in an Increase in Subtilosin Production and a Decrease in Subtilin Production.Probiotics and antimicrobial proteins · 2020Article
- Article
- The effect ofIranian journal of microbiology · 2019Article
- In vitro inhibition of avian pathogenic Enterococcus cecorum isolates by probiotic Bacillus strains.Poultry science · 2019Article
- Article
- Characterization of a Newly Isolated Probiotic Strain fromIndian journal of microbiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome Bacillus strains have recently been identified for potential use as probiotics and food additives. The present study evaluated the antimicrobial effects of Bacillus subtilis ATCC 6633 and its metabolite on the enterotoxin and vegetative cells, spore and germinated spore of Clostridium perfringens type A in Caco-2 cells.
resultsWe used flow cytometry and MTT assays to evaluate the cytotoxicity effect of treatments. According to the results, the most cell survival was found in the 4% crude antimicrobial substance (CAS) with the vegetative form of C. perfringens among co-cultured groups. Furthermore, the apoptosis and necrosis in co-cultured groups were significantly decreased (P < 0.05).
conclusionThe present results suggested the crucial role of the current probiotic in the control of various forms of C. perfringens type A which was investigated for the first time. Also, the majority of treatments showed higher cell viability in flow cytometry compared to the MTT assay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.