ArticleUltrasonic imaging2017
Material Properties of Human Ocular Tissue at 7-µm Resolution.
Article in Ultrasonic imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic.Theranostics · 2023Pooled it
- Thermal Tissue Modeling of the Ciliary Body With Continuous Wave Transscleral Cyclophotocoagulation and Transscleral Laser Therapy Using MicroPulse Technology.Translational vision science & technology · 2025Article
- Enhancing 3-D Radio Frequency Data in Quantitative Acoustic Microscopy Using Quantum-Driven Prior at 250 MHz and 500 MHz.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- The Contribution of the Limbus and Collagen Fibrils to Corneal Biomechanical Properties: Estimation of the Low-Strain In Vivo Elastic Modulus and Tissue Strain.Biomimetics (Basel, Switzerland) · 2024Article
- Biomechanical changes occur in myopic choroidal stroma and mirror those in the adjacent sclera.Communications engineering · 2024Article
- A Quantum Denoising-Based Resolution Enhancement Framework for 250-MHz and 500-MHz Quantitative Acoustic Microscopy.IEEE transactions on computational imaging · 2024Article
- Scanning Laser Ophthalmoscopy Demonstrates Disc and Peripapillary Strain During Horizontal Eye Rotation in Adults.American journal of ophthalmology · 2023Article
- Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions.Micromachines · 2023Review
- Advanced Topics in Quantitative Acoustic Microscopy.Advances in experimental medicine and biology · 2023Article
- High-Frequency Ultrasound Activation of Perfluorocarbon Nanodroplets for Treatment of Glaucoma.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Regional changes in the elastic properties of myopic Guinea pig sclera.Experimental eye research · 2019Article
- Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea.Translational vision science & technology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Quantitative assessment of the material properties of ocular tissues can provide valuable information for investigating several ophthalmic diseases. Quantitative acoustic microscopy (QAM) offers a means of obtaining such information, but few QAM investigations have been conducted on human ocular tissue. We imaged the optic nerve (ON) and iridocorneal angle in 12-µm deparaffinized sections of the human eye using a custom-built acoustic microscope with a 250-MHz transducer (7-µm lateral resolution). The two-dimensional QAM maps of ultrasound attenuation (α), speed of sound ( c), acoustic impedance ( Z), bulk modulus ( K), and mass density (ρ) were generated. Scanned samples were then stained and imaged by light microscopy for comparison with QAM maps. The spatial resolution and contrast of scanning acoustic microscopy (SAM) maps were sufficient to resolve anatomic layers of the retina (Re); anatomic features in SAM maps corresponded to those seen by light microscopy. Significant variations of the acoustic parameters were found. For example, the sclera was 220 MPa stiffer than Re, choroid, and ON tissue. To the authors' knowledge, this is the first systematic study to assess c, Z, K, ρ, and α of human ocular tissue at the high ultrasound frequencies used in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.