ArticleJournal of intensive care medicine2019
Frailty Syndrome and Risk of Sepsis in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort.
Article in Journal of intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- Impact of sarcopenia and frailty on outcomes of patients with sepsis or septic shock: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Frailty as a predictor of mortality and morbidity after cholecystectomy: A systematic review and meta-analysis of cohort studies.Langenbeck's archives of surgery · 2024Pooled it
- Association between hospital frailty risk score, risk of sepsis and adverse outcomes across all adult ages.PloS one · 2026Article
- Integrated Care at Home: A Novel Home-Based Medical Care Program for Community-Dwelling Frail Older Adults in Hong Kong.Annals of geriatric medicine and research · 2025Observational
- Postoperative Adverse Outcomes in Patients With Frailty Undergoing Urologic Surgery Among American Patients: A Propensity-Score Matched Retrospective Cohort Study.Clinical epidemiology · 2025Article
- Body Mass Index and Cause-Specific Mortality after Lung Transplantation in the United States.Annals of the American Thoracic Society · 2023Article
- Social Determinants of Health Associated With the Development of Sepsis in Adults: A Scoping Review.Critical care explorations · 2022Article
- Review
- Epidemiology and clinical features of common community human coronavirus disease.Journal of thoracic disease · 2021Article
- Phase Angle and Frailty Are Important Prognostic Factors in Critically Ill Medical Patients: A Prospective Cohort Study.The journal of nutrition, health & aging · 2021Article
- Mediating Effects of Frailty Indicators on the Risk of Sepsis After Cancer.Journal of intensive care medicine · 2020Article
- The Malnutritional Status of the Host as a Virulence Factor for New Coronavirus SARS-CoV-2.Frontiers in medicine · 2020Article
- Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study.BMC research notes · 2018Article
- Long- and short-term outcomes after transvenous lead extraction in a large single-centre patient cohort using the clinical frailty scale as a risk assessment tool.Indian pacing and electrophysiology journalArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
background: Frailty is associated with increased morbidity and mortality in older persons. We sought to characterize the associations between the frailty syndrome and long-term risk of sepsis in a large cohort of community-dwelling adults.
methods: We analyzed data on 30 239 community-dwelling adult participants in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We defined frailty as the presence of at least 2 frailty indicators (weakness, exhaustion, and low physical activity). We defined sepsis as hospitalization for a serious infection with ≥2 system inflammatory response syndrome criteria, identified for the period 2003-2012. We determined the associations between frailty and risk of first sepsis and sepsis 30-day case fatality.
results: Among REGARDS participants, frailty was present in 6018 (19.9%). Over the 10-year observation period, there were 1529 first-sepsis hospitalizations. Frailty was associated with increased risk of sepsis (adjusted hazard ratio [HR] 1.44; 95% CI: 1.26 to 1.64). The total number of frailty indicators was associated with increased risk of sepsis ( P trend <.001). Among first-sepsis hospitalizations, frailty was associated with increased sepsis 30-day case fatality (adjusted OR 1.62; 95% CI: 1.06 to 2.50).
conclusions: In the REGARDS cohort, frailty was associated with increased long-term risk of sepsis and sepsis 30-day case fatality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.