ReviewJournal of neuroendocrinology2018
Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels.
Review in Journal of neuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Hypothalamic insulin resistance in type 2 diabetes is localized to the posterior hypothalamus.JCI insight · 2026Article
- TOX3 in hypothalamic POMC-lineage cells regulates energy balance via the PTEN-AKT signaling axis.Nature communications · 2026Article
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.The EMBO journal · 2024Article
- A biological rhythm in the hypothalamic system links sleep-wake cycles with feeding-fasting cycles.Scientific reports · 2024Article
- KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Canonical transient receptor potential channels and hypothalamic control of homeostatic functions.Journal of neuroendocrinology · 2024Review
- Article
- Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices.Medical sciences (Basel, Switzerland) · 2024Review
- Review
- Could Naringenin Participate as a Regulator of Obesity and Satiety?Molecules (Basel, Switzerland) · 2023Review
- Insulin action in the brain: cell types, circuits, and diseases.Trends in neurosciences · 2022Review
- Review
- The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis.Frontiers in endocrinology · 2022Review
- GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6.The Journal of biological chemistry · 2021Article
- The brain as an insulin-sensitive metabolic organ.Molecular metabolism · 2021Review
- Chemogenetic approaches to identify metabolically important GPCR signaling pathways: Therapeutic implications.Journal of neurochemistry · 2021Review
- Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia.Nature communications · 2021Article
- Adaptive Changes in the Central Control of Energy Homeostasis Occur in Response to Variations in Energy Status.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Pro-opiomelanocortin (POMC) neurones within the hypothalamic arcuate nucleus are vital anorexigenic neurones. Both the insulin receptor and leptin receptor are coupled to activation of phosphatidylinositide-3 kinase (PI3K) to regulate multiple functions that increase POMC neuronal excitability. Using whole-cell recording in several mammalian species, we have found that both insulin and leptin depolarised POMC neurones via activation of transient receptor potential (TRPC)5 channels. TRPC5 channels have been rigorously characterised as the downstream effector based on their biophysical properties, pharmacological profile, and localisation by immunocytochemistry and single-cell reverse transcriptase-polymerase chain reaction. By contrast, insulin and leptin hyperpolarise and inhibit neuropeptide Y/agouti-related peptide neurones via activation of K
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.