Evidence map›Paper›PMID 28675497›Full record

ArticleMagnetic resonance in medicine2018

Intracellular water preexchange lifetime in neurons and astrocytes.

Donghan M Yang, James E Huettner, G Larry Bretthorst, Jeffrey J Neil, Joel R Garbow, Joseph J H Ackerman

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Trial
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  9. Article
  10. In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. DCE-MRI of Brain Fluid Barriers:Tissue barriers · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Donghan M YangDepartment of Chemistry, Washington University, St. Louis, Missouri, USA.ORCID 0000-0003-1935-0214
James E HuettnerDepartment of Cell Biology and Physiology, Washington University, St. Louis, Missouri, USA.
G Larry BretthorstDepartment of Radiology, Washington University, St. Louis, Missouri, USA.
Jeffrey J NeilDepartment of Neurology, Washington University, St. Louis, Missouri, USA.
Joel R GarbowDepartment of Radiology, Washington University, St. Louis, Missouri, USA.
Joseph J H AckermanDepartment of Chemistry, Washington University, St. Louis, Missouri, USA.

Funding

GLUTAMATE-GATED CHANNELS IN CENTRAL/PERIPHERAL NEURONSR01NS030888 · NINDS · WASHINGTON UNIVERSITY · PI HUETTNER, JAMES E · 1992 to 2016
$4.4M
CNS INJURY: MECHANISM(S) OF DWI CONTRASTR01EB002083 · NIBIB · WASHINGTON UNIVERSITY · PI ACKERMAN, JOSEPH J. H., NEIL, JEFFREY J. · 2003 to 2011
$2.7M
NIBIB NIH HHS R01 EB002083NINDS NIH HHS R01 NS030888
6 · The paper itself

Abstract

purposeTo determine the intracellular water preexchange lifetime, τ

methodsHerein, τ

resultsUnder normal culture conditions, τ

conclusionsGiven an approximate intra- to extracellular volume ratio of 4:1 in the brain, these data imply that, under normal physiological conditions, an MR experimental characteristic time of less than 0.012 s is required for a nonexchanging, two-compartment (intra- and extracellular) model to be valid for MR studies. This characteristic time shortens significantly (i.e., 0.004 s) under injury conditions. Magn Reson Med 79:1616-1627, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Indexed as

WaterAnimalsAstrocytesCells, CulturedCerebral CortexIntracellular SpaceMagnetic Resonance SpectroscopyNeuronsRatsRats, Long-EvansWatercerebral cortexcultured cellsmagnetic resonanceratrelaxation

Identifiers

PMID28675497
PMCPMC5754269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.