Evidence map›Paper›PMID 28675470›Full record

ArticleBritish journal of pharmacology2017

Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT

Takahiro Shimizu, Shogo Shimizu, Naoki Wada, Shun Takai, Nobutaka Shimizu, Youichirou Higashi, Katsumi Kadekawa, Tsuyoshi Majima, Motoaki Saito, Naoki Yoshimura

Open access · bronzeAbstract read
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In one paragraph

Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2A and 5-hydroxytryptamine 7 receptors.International journal of urology : official journal of the Japanese Urological Association · 2020
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Takahiro ShimizuDepartment of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.ORCID http://orcid.org/0000-0002-1555-2284
Shogo ShimizuDepartment of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Naoki WadaDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-9587-6798
Shun TakaiDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nobutaka ShimizuDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Youichirou HigashiDepartment of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Katsumi KadekawaDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Tsuyoshi MajimaDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Motoaki SaitoDepartment of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Naoki YoshimuraDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · USKōchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePsychological stress exacerbates symptoms of urinary bladder dysfunction; however, the underlying brain mechanisms are unclear. We have demonstrated that centrally administered bombesin, a stress-related neuropeptide, facilitates the rat micturition reflex. Brain bombesin-like peptides modulate the serotoninergic nervous system activity under stress conditions; therefore, we examined whether brain 5-HT is involved in the bombesin-induced increased frequency of urination in urethane-anaesthetised male Sprague-Dawley rats. EXPERIMENTAL APPROACH: Evaluation of intercontraction intervals (ICI) and maximal voiding pressure (MVP) during cystometrograms were started 1 h before i.c.v. administration of bombesin or i.c.v. pretreatment with the 5-HT receptor antagonists. KEY

resultsBombesin (0.03 nmol per animal, i.c.v.) significantly reduced ICI without affecting MVP. The bombesin-induced response was significantly suppressed by acute depletion of brain 5-HT, which was induced by pretreatment with p-chlorophenylalanine, a 5-HT synthesis inhibitor. Bombesin at a lower dose (0.01 nmol per animal, i.c.v.) showed no significant effect on ICI, while it significantly reduced ICI in the presence of WAY-100635 (5-HT CONCLUSIONS AND IMPLICATIONS: The brain serotoninergic nervous system is involved in the facilitation of the rat micturition reflex induced by bombesin-like peptides at least in part through brain 5-HT

Indexed as

AnimalsAutonomic Nervous SystemBombesinBrainDose-Response Relationship, DrugInjections, IntraventricularMalePiperazinesPyridinesRatsRats, Sprague-DawleyReceptors, SerotoninSerotonin Receptor AgonistsStructure-Activity RelationshipUrinationBombesinN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidePiperazinesPyridinesReceptors, Serotoninserotonin 7 receptorSerotonin Receptor Agonists

Identifiers

PMID28675470
PMCPMC5573417
OpenAlexW2725646210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.