ArticleThe New phytologist2018
Two proteases with caspase-3-like activity, cathepsin B and proteasome, antagonistically control ER-stress-induced programmed cell death in Arabidopsis.
Article in The New phytologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant-Pathogen Interface.Plant biotechnology journal · 2026Review
- 5-azacytidine affects triticale microspore embryogenesis and is associated with modulation of reactive oxygen species, cysteine protease profiles, and programmed cell death.BMC plant biology · 2026Article
- Plant caspase-like proteins: from function identification to application in winter rapeseed genetic breeding.Frontiers in plant science · 2026Review
- Expression of a constitutively active nitrate reductase increases SARS-CoV-2 Spike protein production in Nicotiana benthamiana leaves that otherwise show traits of senescence.Plant biotechnology journal · 2026Article
- CRISPR-Cas9-mediated editing ofGM crops & food · 2025Article
- The challenges of co-extraction of animal and plant proteins from transgenic plants for use in food and feed.Frontiers in plant science · 2025Review
- γ-Aminobutyric Acid Alleviates Programmed Cell Death in TwoInternational journal of molecular sciences · 2024Article
- Integrated Biological Experiments and Proteomic Analyses ofInternational journal of molecular sciences · 2024Article
- Programmed cell death regulator BAP2 is required for IRE1-mediated unfolded protein response in Arabidopsis.Nature communications · 2024Article
- Cathepsin B degrades RbcL during freezing-induced programmed cell death in Arabidopsis.Plant cell reports · 2024Article
- Plant cathepsin B, a versatile protease.Frontiers in plant science · 2024Review
- Enterotoxins A and B produced byHeliyon · 2023Article
- Vacuolar Processing Enzymes in Plant Programmed Cell Death and Autophagy.International journal of molecular sciences · 2023Review
- Structural and functional characteristics and expression profile of the 20S proteasome gene family in Sorghum under abiotic stress.Frontiers in plant science · 2023Article
- A Pipeline to Monitor Proteasome Homeostasis in Plants.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A Novel Senescence-Specific Gene (International journal of molecular sciences · 2022Article
- Unprocessed wheat γ-gliadin reduces gluten accumulation associated with the endoplasmic reticulum stress and elevated cell death.The New phytologist · 2022Article
- Article
- How Cysteine Protease GeneInternational journal of molecular sciences · 2021Article
- Short-term waterlogging-induced autophagy in root cells of wheat can inhibit programmed cell death.Protoplasma · 2021Article
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5 authors at 2 institutions in 2 countries.
Funding
Abstract
Programmed cell death (PCD) induced by endoplasmic reticulum (ER) stress is implicated in various plant physiological processes, yet its mechanism is still elusive. An activation of caspase-3-like enzymatic activity was clearly demonstrated but the role of the two known plant proteases with caspase-3-like activity, cathepsin B and proteasome subunit PBA1, remains to be established. Both genetic downregulation and chemical inhibition were used to investigate the function of cathepsin B and PBA1 in ER-stress-induced PCD (ERSID). Transcript level and activity labelling of cathepsin B were used to assess activation. To study tonoplast rupture, a plant PCD feature, both confocal and electronic microscopies were used. Cathepsin B downregulation reduced reactive oxygen species (ROS) accumulation and ERSID without affecting the induction of the unfolded protein response (UPR), but downregulation of PBA1 increased UPR and ERSID. Tonoplast rupture was not altered in the cathepsin B mutant and cathepsin B activation was independent of vacuolar processing enzyme (VPE). VPE activity was independent of cathepsin B. ERSID is regulated positively by cathepsin B and negatively by PBA1, revealing a complex picture behind caspase-3-like activity in plants. Cathepsin B may execute its function after tonoplast rupture and works in parallel with VPE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.