Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM).

Natsuko Yamagata, Xiaoyi Chen, Jie Zhou, Jie Li, Xuewen Du, Bing Xu

Abstract read

In one paragraph

Article in Organic & biomolecular chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Enzymatic Noncovalent Synthesis.Chemical reviews · 2020
Review
Enzymatic Noncovalent Synthesis of Supramolecular Soft Matter for Biomedical Applications.Matter · 2019
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natsuko YamagataDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.

Xiaoyi ChenDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.

Jie ZhouDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.

Jie LiDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.

Xuewen DuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.

Bing XuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.ORCID http://orcid.org/0000-0002-4639-387X

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026

$6.4M

NCI NIH HHS R01 CA142746

6 · The paper itself

Abstract

Here we show the first example of an immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, to self-assemble in water via enzyme-instructed self-assembly. Upon enzymatic dephosphorylation, the phosphohexapeptides become hexapeptides, which self-assemble in water to result in supramolecular hydrogels. This work illustrates a new approach to design bioinspired soft materials from a less explored, but important pool of immunomodulatory peptides.

Indexed as

Alkaline PhosphataseCell LineCell SurvivalHeLa CellsHumansImmunoreceptor Tyrosine-Based Inhibition MotifOptical ImagingPeptidesAlkaline PhosphatasePeptides

Identifiers

PMID28675212

DOI10.1039/c7ob01074e

PMCPMC5561744

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.