Evidence map›Paper›PMID 28675189›Full record

ArticleThe journal of the Royal College of Physicians of Edinburgh2017

Evolocumab and clinical outcomes in patients with cardiovascular disease.

S Hadjiphilippou, K K Ray

Registry-linked trialAbstract readComment
PubMed Publisher
In one paragraph

Article in The journal of the Royal College of Physicians of Edinburgh, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05001984 (Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-label, Blinded End-point Study with High-resolution MR Vessel Wall Imaging), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05001984 phase2active not recruitingstarted 2021, after this paper: background citation

Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-label, Blinded End-point Study with High-resolution MR Vessel Wall Imaging

Ran2021Enrolled60Registered outcomes11Posted comparisons0ConditionsAcute Ischemic Stroke, ICAS - Intracranial Atherosclerosis, Intracranial AtherosclerosisArmsAlirocumab
Open the trial in the graph
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Vascular Macrophages in Atherosclerosis.Journal of immunology research · 2019
    Review
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

S HadjiphilippouKK Ray, Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College, London W6 8RP, UK. Email: k.ray@imperial.ac.uk.
K K Ray

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anticholesteremic AgentsCardiovascular DiseasesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedHumansAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAnticholesteremic Agentsevolocumab

Identifiers

PMID28675189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.