Evidence map›Paper›PMID 28674869›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2017

Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study.

Sarah L Hissen, Khadigeh El Sayed, Vaughan G Macefield, Rachael Brown, Chloe E Taylor

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Impact of maternal obesity on resting muscle sympathetic nerve activity during uncomplicated pregnancy: a longitudinal assessment.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  4. Review
  5. Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
  6. Neural control of blood pressure during pregnancy in humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sarah L HissenSchool of Science and Health, Western Sydney University, Campbelltown Campus, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia.
Khadigeh El SayedSchool of Medicine, Western Sydney University, Sydney, Australia.
Vaughan G MacefieldSchool of Medicine, Western Sydney University, Sydney, Australia.
Rachael BrownSchool of Medicine, Western Sydney University, Sydney, Australia.
Chloe E TaylorSchool of Science and Health, Western Sydney University, Campbelltown Campus, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia. C.Taylor@westernsydney.edu.au.
Western Sydney University · AUMohammed Bin Rashid University of Medicine and Health Sciences · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE AND

methodsMuscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy.

resultsMuscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout.

interpretationThe increase in sympathetic outflow early in pregnancy cannot be explained by a reduction in baroreflex sensitivity, while the secondary increase in burst frequency in the third trimester may, in part, be explained by the elevated heart rate.

Indexed as

Adrenergic FibersAdultBaroreflexBlood PressureFemaleHeart RateHumansInfant, NewbornLongitudinal StudiesMuscle, SkeletalPregnancyPregnancy Trimester, FirstSympathetic Nervous SystemBaroreflex sensitivityBlood pressureMicroneurographyPregnancy

Identifiers

PMID28674869
OpenAlexW2728521338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.