Evidence map›Paper›PMID 28674788›Full record

ArticleNeurotoxicity research2017

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom.

Daryl C Yang, James Dobson, Chip Cochran, Daniel Dashevsky, Kevin Arbuckle, Melisa Benard, Leslie Boyer, Alejandro Alagón, Iwan Hendrikx, Wayne C Hodgson and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. First Insights into the Venom Composition of Two Ecuadorian Coral Snakes.International journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Epidemiology, Clinical Features, and Management of Texas Coral Snake (Micrurus tener) Envenomations Reported to the North American Snakebite Registry.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Daryl C YangMonash Venom Group, Monash University, Clayton, VIC, 3800, Australia.
James DobsonVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072, Australia.
Chip CochranDepartment of Earth and Biological Sciences, Loma Linda University, Loma Linda, CA, 92350, USA.
Daniel DashevskyVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072, Australia.
Kevin ArbuckleDepartment of Biosciences, College of Science, Swansea University, Swansea, SA2 8PP, UK.
Melisa BenardInstituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, 62210, Cuernavaca, Morelos, Mexico.
Leslie BoyerVenom Immunochemistry, Pharmacology and Emergency Response (VIPER) Institute, University of Arizona College of Medicine, Tucson, AZ, USA.
Alejandro AlagónInstituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, 62210, Cuernavaca, Morelos, Mexico.
Iwan HendrikxMonash Venom Group, Monash University, Clayton, VIC, 3800, Australia.
Wayne C HodgsonMonash Venom Group, Monash University, Clayton, VIC, 3800, Australia. wayne.hodgson@monash.edu.
Bryan G FryVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072, Australia. bgfry@uq.edu.au.ORCID http://orcid.org/0000-0001-6661-1283
The University of Queensland · AUMonash University · AUUniversidad Nacional Autónoma de México · MXLoma Linda University · USMonash Health · AUSwansea University · GBUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coral snake envenomations are well characterized to be lethally neurotoxic. Despite this, few multispecies, neurotoxicity and antivenom efficacy comparisons have been undertaken and only for the Micrurus genus; Micruroides has remained entirely uninvestigated. As the USA's supplier of antivenom has currently stopped production, alternative sources need to be explored. The Mexican manufacturer Bioclon uses species genetically related to USA species, thus we investigated the efficacy against Micrurus fulvius (eastern coral snake), the main species responsible for lethal envenomations in the USA as well as additional species from the Americas. The use of Coralmyn® coral snake antivenom was effective in neutralizing the neurotoxic effects exhibited by the venom of M. fulvius but was ineffective against the venoms of Micrurus tener, Micrurus spixii, Micrurus pyrrhocryptus, and Micruroides euryxanthus. Our results suggest that the Mexican antivenom may be clinically useful for the treatment of M. fulvius in the USA but may be of only limited efficacy against the other species studied.

Indexed as

AnimalsAntiveninsChickensCoral SnakesElapid VenomsMaleMiceNeurotoxinsPhylogenySpecies SpecificityAntiveninsElapid VenomsNeurotoxinsAntivenomCoral snakeMicruroidesMicrurusNeurotoxicityVenom

Identifiers

PMID28674788
OpenAlexW2728063140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.