ArticleBrain imaging and behavior2018
Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.
Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Large-scale network dysfunction in the acute state compared to the remitted state of bipolar disorder: A meta-analysis of resting-state functional connectivity.EBioMedicine · 2020Pooled it
- Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression.Journal of translational medicine · 2025Trial
- White Matter Abnormalities in Bipolar II and Unipolar Depression - Evidence from Fixel-Based Analysis.medRxiv : the preprint server for health sciences · 2026Article
- SNP-associated differential methylation inEpigenomics · 2025Article
- Unraveling the enigma of mental disorders: a genetics-first approach and the role of mouse models based on rare disease-susceptible genome variants.Nagoya journal of medical science · 2025Review
- Provincial and connector qualities of somatosensory brain network hubs in bipolar disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Review
- Stronger tilt aftereffects in individuals diagnosed with schizophrenia spectrum disorders but not bipolar disorder.Schizophrenia research · 2024Article
- Classification of bipolar disorders using the multilayer modularity in dynamic minimum spanning tree from resting state fMRI.Cognitive neurodynamics · 2023Article
- Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I.Journal of affective disorders · 2023Article
- A Comprehensive Overview of the Role of Visual Cortex Malfunction in Depressive Disorders: Opportunities and Challenges.Neuroscience bulletin · 2023Review
- Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study.Cerebellum (London, England) · 2023Article
- Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Functional Connectivity of the Cerebellar Vermis in Bipolar Disorder and Associations with Mood.bioRxiv : the preprint server for biology · 2023Article
- Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach.Frontiers in psychiatry · 2023Article
- Article
- Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.Brain imaging and behavior · 2022Article
- Metabolic abnormalities in the basal ganglia and cerebellum in bipolar disorder: A multi-modal MR study.Journal of affective disorders · 2022Article
- Grey and white matter alteration in euthymic children with bipolar disorder: a combined source-based morphometry (SBM) and voxel-based morphometry (VBM) study.Brain imaging and behavior · 2022Article
- Cerebellum and Emotion in Social Behavior.Advances in experimental medicine and biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Bipolar disorder is characterized by recurring episodes of depression and mania. Defining differences in brain function during these states is an important goal of bipolar disorder research. However, few imaging studies have directly compared brain activity between bipolar mood states. Herein, we compare functional magnetic resonance imaging (fMRI) responses during a flashing checkerboard stimulus between bipolar participants across mood states (euthymia, depression, and mania) in order to identify functional differences between these states. 40 participants with bipolar I disorder and 33 healthy controls underwent fMRI during the presentation of the stimulus. A total of 23 euthymic-state, 16 manic-state, 15 depressed-state, and 32 healthy control imaging sessions were analyzed in order to compare functional activation during the stimulus between mood states and with healthy controls. A reduced response was identified in the visual cortex in both the depressed and manic groups compared to euthymic and healthy participants. Functional differences between bipolar mood states were also observed in the cerebellum, thalamus, striatum, and hippocampus. Functional differences between mood states occurred in several brain regions involved in visual and other sensory processing. These differences suggest that altered visual processing may be a feature of mood states in bipolar disorder. The key limitations of this study are modest mood-state group size and the limited temporal resolution of fMRI which prevents the segregation of primary visual activity from regulatory feedback mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.