ArticlePediatric nephrology (Berlin, Germany)2017
Characteristics of hypertension in premature infants with and without chronic lung disease: a long-term multi-center study.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07547917 (Improving the Measurement of Neonatal High Blood Pressure Using the Boppli Device), which is not on this map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving the Measurement of Neonatal High Blood Pressure Using the Boppli Device
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Blood pressure trajectories in extreme preterm infants with and without bronchopulmonary dysplasia: a longitudinal cohort study.BMC pediatrics · 2026Article
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- Neonatal intermittent hypoxemia events are associated with later systemic hypertension.Pediatric research · 2025Article
- Blood pressure in preterm infants with bronchopulmonary dysplasia in the first three months of life.Pediatric nephrology (Berlin, Germany) · 2024Article
- Cardiovascular Sequelae of Bronchopulmonary Dysplasia in Preterm Neonates Born before 32 Weeks of Gestational Age: Impact of Associated Pulmonary and Systemic Hypertension.Journal of cardiovascular development and disease · 2024Review
- Blood Pressure Outcomes in NICU-Admitted Infants with Neonatal Hypertension: A Pediatric Nephrology Research Consortium Study.The Journal of pediatrics · 2024Article
- Systemic hypertension in preterm infants and neurodevelopmental outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Normative values of renin and aldosterone in clinically stable preterm neonates.Pediatric nephrology (Berlin, Germany) · 2023Article
- Phthalates cause a low-renin phenotype commonly found in premature infants with idiopathic neonatal hypertension.Pediatric nephrology (Berlin, Germany) · 2023Review
- Bartter Syndrome: Perspectives of a Pediatric Nephrologist.Electrolyte & blood pressure : E & BP · 2022Review
- Neonatal hypertension: concerns within and beyond the neonatal intensive care unit.Clinical and experimental pediatrics · 2022Article
- Article
- Anuria in neonatal intensive care: Answers.Pediatric nephrology (Berlin, Germany) · 2020Article
- The changing spectrum of hypertension in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Pulmonary Function and Systolic Blood Pressure in Very Low Birth Weight Infants at 34 - 36 Weeks of Corrected Age.Research and reports in neonatology · 2019Article
- Phthalate-associated hypertension in premature infants: a prospective mechanistic cohort study.Pediatric nephrology (Berlin, Germany) · 2019Observational
- Neonatal hypertension: an educational review.Pediatric nephrology (Berlin, Germany) · 2019Review
- Neonatal hypertension: cases, causes, and clinical approach.Pediatric nephrology (Berlin, Germany) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany causes for neonatal hypertension in premature infants have been described; however in some cases no etiology can be attributed. Our objectives are to describe such cases of unexplained hypertension and to compare hypertensive infants with and without chronic lung disease (CLD).
methodsWe reviewed all cases of hypertension in premature infants referred from 18 hospitals over 16 years. Inclusion criteria were hypertension occurring at <6 months of age and birth at <37 weeks gestation; the main exclusion criterion was known secondary hypertension. Continuous variables were compared using analysis of variance. Nominal variables were compared using chi-square tests.
resultsA total of 97 infants met the inclusion criteria, of whom 37 had CLD. Among these infants, hypertension presented at a mean of 11.3 ± 3.2 chronological weeks of age and a postmenstrual age of 39.6 ± 3.6 weeks. Diagnostic testing was notable for plasma renin activity (PRA) being <11 ng/mL/h in 98% of hypertensive infants. Spironolactone was effective monotherapy in 51 of 56 cases of hypertension. Hypertension resolved in all infants, with an average treatment duration of 25 weeks. Significant differences between the two groups of infants were a 0.4 kg lower birthweight and a 2.5 weeks younger gestational age at birth in those with CLD (p < 0.01, p < 0.01, respectively). Hypertension presented in those with CLD 1.8 weeks later, but at the same postmenstrual age as those without CLD (p < 0.01, p = 0.45, respectively).
conclusionPremature infants with unexplained hypertension, with and without CLD, presented at a postmenstrual age of 40 weeks with low PRA, transient time course, and a favorable response to spironolactone treatment.
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