ArticleOpen heart
Risk and outcomes of aortic valve endocarditis among patients with bicuspid and tricuspid aortic valves.
Article in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Mitral annulus calcification and the risk of infective endocarditis: insights from DANCAVAS screening trials.European heart journal open · 2026Article
- Infective Endocarditis on Aortic Valve: From Diagnosis to Cardiac Surgical Intervention-Narrative Review.Journal of clinical medicine · 2026Review
- Early outcomes and predictors of mortality in native aortic valve endocarditis: results from a national registry.Open heart · 2026Article
- Article
- A case of stroke as a unique sign of subclinical infective endocarditis by Abiotrophia defectiva: a case report.International journal of emergency medicine · 2025Article
- Bicuspid Morphology and Rapid Deployment Valve Replacement: Is This Still a Contraindication?Journal of clinical medicine · 2023Article
- Infective endocarditis risk in patients with bicuspid aortic valve: Systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2023Review
- Multiple complications of a well-known disease: a case report of acquired Gerbode defect after bicuspid aortic valve endocarditis.European heart journal. Case reports · 2023Article
- The Natural History of Bicuspid Aortic Valve Disease.Structural heart : the journal of the Heart Team · 2023Review
- Current Views on Infective Endocarditis: Changing Epidemiology, Improving Diagnostic Tools and Centering the Patient for Up-to-Date Management.Life (Basel, Switzerland) · 2023Review
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- Article
- Surgery for endocarditis in patients with bicuspid aortic valves.Annals of cardiothoracic surgery · 2022Article
- Article
- Commentary: Bicuspid aortic valve endocarditis-a different disease?JTCVS open · 2021Article
- Transaortic approach for combined aortotricuspid valve endocarditis.JTCVS techniques · 2021Article
- Infective Endocarditis Involving Mitral and Aortic Valves With Interatrial Septal Abscess.Cureus · 2021Article
- Article
- A rare case of anaerobic streptococci endocarditis in a young female with bicuspid aortic valve: case report.European heart journal. Case reports · 2021Article
- Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivePatients with structural abnormalities of cardiac valves, including bicuspid aortic valve (BAV), are said to be at higher risk of infective endocarditis (IE). We sought to determine the risk of IE of the BAV compared with the tricuspid aortic valve (TAV) and to determine the risk of aortic valve replacement and mortality after IE.
methodsFrom medical records of two US and one Italian hospitals, patients with their first episode of IE of any native valve were identified. In the US cohort 42 patients with BAV and 393 patients with TAV with IE occurring between 1 January 2000 and 30 June 2014 were identified. In the Italian cohort 48 patients with BAV and 341 patients with TAV with IE underwent valve replacement surgery between 1 January 2000 and1 November 2015. The risk of IE for BAV and TAV and subsequent outcomes were determined after matching to patients without IE.
resultsAfter adjustment for risk factors, the risk of IE in the US cohort was 23.1 (95% CI 8.1 to 100, p <0.0001) times greater for BAV than TAV. Patients with BAV with IE were more likely to have an aortic root abscess. Within the subsequent 5 years, BAV patients with IE were more likely to undergo valve replacement (85%) than TAV patients with IE (46%). Patients with IE were at increased risk of death. The findings were similar in the Italian cohort.
conclusionsPatients with BAV are at markedly increased risk of IE and aortic root abscess than patients with TAV. Increased risk of IE in patients with BAV indicates they may be a candidate group for long-term trials of antibiotic prophylaxis of IE.
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